Shachi Mittal

Dr. Shachi Mittal's research advances cancer diagnostics and treatment through computational pathology and spatial biology. Her work integrates artificial intelligence with quantitative tissue analysis to develop high-throughput platforms for immune cell identification and diagnostic segmentation pipelines. In cancer research, she employs multispectral imaging combined with advanced image analytics to generate spatial distribution maps quantifying cellular interactions within the tumor microenvironment. Her lab also combines imaging with spatial transcriptomics to identify biomarkers predictive of disease progression and treatment response. In chronic kidney disease, her team developed FibAI, a multi-tiered segmentation pipeline using clustering and proximity-based classification algorithms to differentiate pathological fibrosis from structural collagen in renal biopsies. These scalable, open-source computational tools enable high-throughput quantitative analysis of tissue morphology and disease progression, bridging pattern recognition, and biomedical applications to transform diagnostic workflows across multiple pathological contexts.

Shachi Mittal is an Assistant Professor in the Department of Chemical Engineering at the University of Washington and an Adjunct Assistant Professor in the Department of Laboratory Medicine and Pathology. She is also an Affiliate faculty at the Fred Hutch Cancer Center. She received her Ph.D. from the Department of Bioengineering at UIUC in 2019. She received her undergraduate in Biochemical Engineering from the Indian Institute of Technology in Delhi in 2014. Her expertise is at the intersection of spectral imaging, immune profiling, cancer biology, pathology, and artificial intelligence. She is passionate about interfacing engineering technologies with clinical science to develop patient driven solutions for diseases like cancer and chronic kidney disease. She is a part of the International Immune Oncology working group. She has received several awards and fellowships, such as the Baxter Young Investigator award, William G. Fateley award, Tomas B. Hirschfeld Scholar award, Illinois Distinguished Fellowship, and Big Data Fellowship for computational medicine.

• Time: 11:00 AM
• Location: 206 Furnas Hall