21st Annual CBE Graduate Student Research Symposium

Friday, October 12, 2018

Keynote Lecture

Dr. Douglas A Lauffenburger |Department of Biological Engineering, Massachusetts Institute of Technology

Humanizing Therapeutics Discovery & Development

Image of Dr. Samir Mitragotri.

The therapeutics discovery/development pipeline involves multiple stages for progress from idea to approved treatment, and has become highly expensive over the past decades mainly due to the large proportion of potential drugs that fail in costly clinical trial stages.  A chief reason for failure in clinical trials following promising findings in preclinical studies is that results in preclinical animal model studies do not generally translate strongly to similar results in human patients due to the incomplete correspondence of animal biology, physiology, and pathology in comparison to that in humans.  Alongside this scientific issue, there exists a level of societal concern about the most appropriate use of animal experimentation.  The therapeutics discovery/development field has been attempting to address the challenge of ‘humanizing’ the pipeline along multiple avenues of research endeavor – prominently including efforts to construct human tissue and organ surrogates outside the body, using stem cell and ‘organ-on-chip’ platform technologies, and machine learning computational modeling approaches to bridge the preclinical-to-clinical divide either with human genomic data or with modeling of animal experiment data.  In this presentation I will outline various approaches to addressing this therapeutics discovery/development challenge, and their current stage of prospect.

Douglas A. Lauffenburger is Ford Professor of Bioengineering and (founding) Head of the Department of Biological Engineering at MIT.  His major research interests are in cell engineering: the fusion of engineering with molecular cell biology, with central focus on systems biology approaches to complex pathophysiology in application to drug discovery and development.  Lauffenburger has co-authored a monograph entitled Receptors: Models for Binding, Trafficking & Signaling, published by Oxford University Press in 1993; he also co-edited the book entitled Systems Biomedicine: Concepts and Perspectives, published by Elsevier in 2010.  More than 100 doctoral students and postdoctoral associates have undertaken research education under his supervision.

Prof. Lauffenburger has served as a consultant or scientific advisory board member for numerous biotechnology and pharmaceutical companies, and his awards include the Galletti Award from AIMBE, the Coburn Award and Walker Award from AIChE, and the Distinguished Lecture Award and Shu Chien Career Achievement Award from BMES.  He is a member of the National Academy of Engineering and the American Academy of Arts & Sciences, and has served as President of the Biomedical Engineering Society, Chair of the College of Fellows of American Institute for Medical & Biological Engineering, on the Advisory Council for NIGMS, and as a co-author of the 2009 NRC report on A New Biology for the 21st Century.

Graduate Student Lectures

Andrew Kroetsch | Doctoral Student in Professor Park's Group

Parham Rohani.

A Platform Engineering Approach for the Design of Recycling Therapeutic Antibodies

Junyi Liu | Doctoral Student in Professor Lin's Group

Yayu Liu.

Highly Polar Polymers with Superior Membrane CO2/N2 Separation Properties for Carbon Capture