Research Facilities
Scientists at the University at Buffalo have extensive access to laboratories and research facilities across campuses, the community, and New York State, enabling some of the most groundbreaking research in the country.
Furnas Hall Materials Characterization Laboratory
Cleanroom
On this page:
Digital Manufacturing Laboratory
Clinical and Translational Science Institute (CTSI) Imaging Center
Confocal Microscopy/Cellular Imaging
Center for Computational Research
Shared Instrument Facilities
South Campus Instrument Center
Chemistry Instrumentation Center
Flow Cytometer
Liquid chromatography-mass spectrometer (LC-MS)
Liquid chromatography-mass spectrometer (LC-MS): This is an LTQ-Orbitrap XL instrument from Thermo integrated with nano-LC. This instrument has a high resolution Orbitrap detector (>60,000 resolution), and collision cells for collision induced dissociation: both low-energy CID and high-energy HCD. Such instrumentation is ideal for the analysis of complex mixtures in the fields of proteomics, glycomics and small molecule analytics.
UB North Campus Confocal Imaging Facility
In 2009, Drs. Jim Berry (Biological Sciences) and Arnd Pralle (Physics) were awarded a National Science Foundation MAJOR RESEARCH INSTRUMENTATION grant to purchase a Zeiss LSM 710 Confocal Microscope.
In addition to the usual laser excitation lines of 405, 458, 488, 514, and 633nm, our Zeiss InTune laser can be tuned to produce any wavelength between 488 and 640 nm. It is one of very few instruments in the country so configured. Emission filtering is accomplished by spectral detectors instead of optical filtering. As a result, the microscope can be set up to image a wider range of fluorescent probes than many confocal microscopes.
The instrument is also equipped with fluorescence lifetime (FLIM) detectors. Since fluorescent molecules exhibit unique lifetimes measurable by FLIM detectors, they can provide an additional parameter to differentiate between probes. More importantly, however, fluorescence lifetime can be used to measure Fluorescence Resonance Energy Transfer (FRET), or intracellular environmental features such as pH, ion concentration, and protein interactions.
Other applications for the instrument include photo activation, spectral scanning, 3 dimensional reconstructions, Fluorescence Recovery after Photo-bleaching (FRAP), examination of samples too thick for wide field fluorescence microscopy, and live cell experiments that would benefit from a heated stage incubator.