Transport phenomena; bioactive surfaces; biological pores; transdermal transport
507 Furnas Hall
Buffalo NY, 14260
Phone: (716) 645-1182
Fax: (716) 645-3822
Research addresses fundamental problems in the transport of molecules and particles in pores, near surfaces and in other types of heterogeneous environments, and the application of such basic theory to mechanistic understanding and technological development in biology and biomedical engineering.
Basic research focuses on the dynamics (“kinetic theory”) of configurational diffusion (rotation, stretching, bending) for nonspherical and flexible molecules. These types of Brownian motion have a particularly rich structure, both geometrically and physicochemically, when they occur in pores or near surfaces, and when they involve intermolecular forces, binding interactions or chemically reactive species. Specific problems studied are: (i) what is the macroscopically observable rate of diffusion and binding of a solute through a medium with a microscopically heterogeneous distribution of binding sites; (ii) how is the rate of a site-specific reaction affected when one of the reacting molecules is immobilized on a surface; and (iii) how