Taylor Boyd studied omega-3 fatty acid regulation of metabolism through pyruvate dehydrogenase in prostate cancer for her project in Roswell Park Comprehensive Cancer Center’s Summer Research Experience Program in Cancer Science.
Students Highlight Projects During 2017 Summer Research Day
September 8, 2017
Seventy-six student-scientists presented projects during the
2017 Buffalo Summer Research Day, an interdisciplinary forum
marking the culmination of their summer research in Buffalo.
The undergraduate and graduate students worked with mentors from
the University at Buffalo and partner institutions to explore
cancer, schizophrenia, cigarette-related studies, infectious
diseases, aging and other areas.
Oncology Expert Delivers Keynote Address
Elizabeth Repasky, PhD, professor of oncology at Roswell
Park Comprehensive Cancer Center, presented the keynote address
titled “Temperature Matters! Or How Old Medical Observations
Can Become New Opportunities in Cancer Research.”
Repasky is the Williams Heubsch Professor of Immunology and a
program leader for the Cell Stress and Biophysical Therapies
program at Roswell Park.
Her translational research program focuses on exploration of
stress and physiological responses, which can be manipulated to
alter the tumor microenvironment and improve the efficacy of cancer
therapies, including radiation, chemotherapies and
A major passion for her has been to understand the role of body
temperature and the impact of mild thermal stress on efficacy of
ionizing radiation, anti-tumor immune activity, vascular function
Repasky has authored or co-authored more than 170 cited
publications and received the J. Eugene Robinson Award from the
Society for Thermal Medicine in 2015.
During her career she has served as major adviser to 21 doctoral
students, 12 postdoctoral fellows and 40 summer interns, nearly all
of whom have gone on to become successful members of the research,
academia or biotech communities.
Displaying Posters, Giving Oral Presentations
During the forum, students from various summer research programs
participated in a poster exposition. One student from each program
was selected to deliver an oral presentation.
The following are research projects for the summer programs
involving the Jacobs School of
Medicine and Biomedical Sciences.
Summer Undergraduate Research Experience (SURE)
- Michael Battaglia presented “Characterization of a Novel
Small Molecule NHR Binding HIV-1 Fusion Inhibitor.” Mentor:
Jacobs, PhD, research associate professor of microbiology and
- Alexander Dimitri presented “iPSC Cerebral Organoids
Reveal Early Developmental Malformations in Schizophrenia.”
K. Stachowiak, PhD, assistant professor of pathology and
- Esther Greeman presented “Rats Initially Drink More
Ethanol When Sweetened With Glucose Than With Fructose.”
E. Bass, PhD, assistant professor of pharmacology and
- Terry Henry presented “Effect of pH and Antibiotics on
Pseudomonas Aeruginosa and Methicillin-Resistant Staphylococcus
Aureus.” Mentor: Mark
Ehrensberger, PhD, assistant professor of biomedical
- Bella Lee presented “ECM Stiffness-Dependent Survivin
Expression and Cellular Function.” Mentor: Yongho
Bae, PhD, assistant professor of pathology and anatomical
- Jacqueline Reid presented “Hypomyelination After Deletion
of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor
Cells is Not Associated with Changes in the Inflammatory Glial
Response.” Mentor: Pablo
M. Paez, PhD, assistant professor of pharmacology and
- Brittany Sincox presented “Disease-Associated Mutation
Changes Kinetics and Permeation of NMDA Receptors.” Mentor:
K. Popescu, PhD, professor of biochemistry.
- Reality Suarez presented “Generating Synthetic Bacterial
Biofilms for Quorum Sensing.” Mentor: Praveen R. Arany, PhD,
DDS, assistant professor of oral biology in the School of Dental
program is directed by Terry
D. Connell, PhD, who is responsible for coordinating the
Buffalo Summer Research Day. Connell is a professor of microbiology
T35 Research Program in Infectious Diseases, Microbiology and Immunology
- Lester Bayona Chuye presented “Brains in a Dish: Growing
Cerebral Organoids to Study Schizophrenia.” Mentor: Michal
K. Stachowiak, PhD, professor of pathology and
- Anisha Chava presented “The Effect of Cherry Flavoring
Electronic Cigarette Aerosols on Pulmonary Inflammation.”
Mentor: Yasmin Thanavala, PhD, professor of immunology at Roswell
- Samantha Eng presented “Expression of IgA Proteases by
Haemophilus Influenzae in Adults with COPD.” Mentor: Timothy
F. Murphy, MD, senior associate dean for clinical and
translational research and SUNY Distinguished Professor
- Thor Vandehei presented “An Investigation of the
Metabolite Transporters PEG344 and PEG1860 From Hypervirulent
Klebsiella Pneumoniae Strain hvKP1.” Mentor: Thomas
A. Russo, MD, professor of medicine and chief of the Division
of Infectious Diseases.
- Narissa Williams presented “Evaluating Current
Methods of HCV Management and Service Delivery for Patients in
Treatment for Substance Use Disorders: Opportunities for
Telemedicine-Based HCV Service Integration.” Mentor: Andrew
H. Talal, MD, professor of medicine.
- Nicolette Winder presented “The Effect of β-AR
Signaling on the Metabolism of CD8+ T Cells During
Activation.” Mentor: Elizabeth Repasky, PhD, professor of
oncology at Roswell Park.
program is co-directed by Murphy and Kelvin
P. Lee, MD, research professor of medicine.
Summer Apprentice Program, Hauptman-Woodward Medical Research Institute
- Kailey Ferger presented “An Evolutionary Analysis of
Ribosomal Protein S4.” Mentor: William
L. Duax, PhD, professor of structural
- Armond June presented “Structure and Biochemical
Characterization of NRPS Adenylation Domains from P. Aeruginosa
Genes 3327 and 4078.” Mentor: Andrew
M. Gulick, PhD, research assistant professor
of structural biology.
- William Schultz presented “Expression and Purification of
GvCOX and GvCOX Mutants.” Mentor: Michael
G. Malkowski, PhD, professor and chair of structural
- Abigail Schwenk presented “Phenotypical Assay of Ole1 in
Yeast.” Mentor: Malikowski.
William Bauer, PhD, coordinates the summer
program at Hauptman-Woodward Medical Research Institute.
BioXFEL Summer Undergraduate Research Experience
- Jermel Griffin presented “Using Molecular Dynamics to
Assess Hydrogen Bond Networks of De Novo Designed Proteins.”
Mentor: Thomas Szyperski, PhD, UB Distinguished Professor of
- Efrain Rodriguez presented “BioAssay Development for the
Chemoactivation of Transforming Growth Factor β1.”
H. Snell, PhD, co-principal investigator and chief executive
officer of the Hauptman-Woodward
Medical Research Institute.
- Shirley Yuen presented “Engineering Cold Denaturing
Proteins.” Mentor: Szyperski.
William Bauer, PhD, coordinates the BioXFEL
Summer Undergraduate Research Experience.
Collaborative Learning and Integrated Mentoring in the Biosciences Undergraduate Program (CLIMB UP)
UP is a summer research program that gives undergraduates
hands-on laboratory experience in biomedical and health
Seven students had projects funded through the American
Society for Pharmacology and Experimental Therapeutics Summer
Undergraduate Research Fellowship:
- Moriah Cobb presented “Exploring Molecular Mechanisms of
Adolescent Sucrose Exposure.” Mentor: David
Dietz, PhD, associate professor and interim chair of pharmacology and
- Caitlin Deubell presented “Flow Cytometry Based
Analytical Method for Quantitation of Blinatumomab (Blincyto®)
in Mouse Plasma.” Mentor: Dhavalkumar K. Shah, PhD, assistant
professor of pharmaceutical sciences.
- Israh Ibrahim presented “Automated Detection and
Quantification of Red Blood Cells from Peripheral Blood
Smear.” Mentor: Pinaki
Sarder, PhD, assistant professor of pathology and
- Zuiru Lin presented “Discovery of Small Anti-Cancer
Molecule Targeting Estrogen Receptor.” Mentor: Rajendram
Rajnarayanan, PhD, assistant professor of pharmacology and
- Michael Olyer presented “Inhibition of Antibiotic
Resistance Induced by the SOS Response: The Effects of Metal
Ionophores.” Mentor: John
K. Crane, MD, PhD, professor of medicine.
- Garrett Sheehan presented “Impact of Carbamate
Insecticides and Phthalate Diester Exposure on Melatonin
Receptor-Mediated Inhibition of CREB Phosphorylation.”
L. Dubocovich, PhD, SUNY Distinguished Professor of
pharmacology and toxicology and senior associate dean for diversity
- Nadin Zejnilovic presented “The Role of TAAR-1 on the
Modulation of Circadian Rhythms in Mice.” Mentor:
Ten students had projects funded by the Institute
for Strategic Enhancement of Educational Diversity Summer Research
- Quinn Carroll presented “Type of Traumatic Life Event
Does Not Influence Future Post-traumatic Growth.” Mentor:
Jennifer Read, PhD, professor of psychology.
- Adriana del Mar Pons Calvo presented “Macrophage
Acetylcholine Receptor Regulation of TNF Production during
Neuropathic Pain.” Mentor: Tracey
A. Ignatowski, PhD, assistant professor of pathology and
- Lindsey Euscher presented “The Role of Protein
Aggregation in the Development of Inhibitors to Eloctate in
Hemophilia A.” Mentor: Sathy V. Balu-Iyer, PhD, professor of
- Aylin Flores presented “Distinguishing Whether Rif2
and Orc4 Subfunctionalized or Neofunctionalized After
Duplication.” Mentor: Laura Rusche, PhD, associate professor
of biological sciences.
- Samantha Manahan presented “American Indians and
Alzheimer’s Disease: A Systematic Review 2006-2016.”
Mentor: Margaret Moss, PhD, associate professor of nursing.
- Brianna Scotland presented “Murine mRNA Expression of a
Novel, Orphan Transporter: Monocarboxylate Transporter 6
(Mct6).” Mentor: Marilyn E. Morris, PhD, SUNY Distinguished
Professor and chair of pharmaceutical sciences.
- LeDaniel Sims presented “Bioengineering with Nano
Scaffolds for Tissue Regeneration.” Mentor: Praveen R. Arany,
PhD, DDS, assistant professor of oral biology in the School of
- Melinda Tiao presented “Scanning Electron Microscopy
(SEM) Assessment of Endothelialization in Elastase Aneurysm Models
Treated with a Retrievable Asymmetric Flow Diverter (RAFD).”
N. Ionita, PhD, research assistant professor of biomedical
- Toni Warnick presented “Histological Evaluation of
Elastase-Induced Rabbit Aneurysms Treated with Retrievable
Asymmetric Flow Diverter [RAFD].” Mentor: Ionita.
- Toneia Washington presented “Analyzing Oral Wound Healing
On Murine Macrophage Cell Lines Using Photobiomodulation.”
Three students had projects funded by the Clinical and Translational
- Dorian Frazier presented “Influence of Starting Material
on Human Monocyte-Derived Dendritic Cells.” Mentor: Jason
Muhitch, PhD, assistant professor of oncology at Roswell Park.
- Nathan Greene presented “A Data Driven Approach to
Studying the Weekend Effect in ICU Patients Receiving
Unfractionated Heparin.” Mentor: Jason
M. Davies, MD, PhD, assistant professor of neurosurgery.
- Coral Sanchez Malave presented “Novel Methods of
Designing Liposome-Based Drug Delivery System into the
Macrophages.” Mentor: Umesh
Sharma, MD, PhD, assistant professor of medicine in
of Cardiovascular Medicine.
Five students were involved with CLIMB
PRO, a division of CLIMB UP for undergraduates interested in
pursuing a medical degree or MD-PhD:
- Justin Harvey presented “Increasing Colorectal Cancer
Screening Rates — A Quality Improvement Initiative.”
O. Diaz Del Carpio, MD, assistant professor of medicine.
- Godstime Nwatu-Ugwu presented “Regulation of the
Extracellular Matrix in Aging and Disease.” Mentor: Te-Chung
Lee, PhD, associate professor of biochemistry.
- Elizabeth Okundaye presented “Predictive Immunoprofiling
for Precision Based Immunotherapy in Triple Negative Breast
Cancer.” Mentor: Wilfrido
D. Mojica, MD, associate professor of pathology and
- Kiam Preston Jr. presented “Investigation of Nonalcoholic
Steatohepatitis (NASH): D-amino Acid Inducing D-amino Acid Oxidase
in Hepatocytes.” Mentor: Lixin
Zhu, PhD, assistant professor of pediatrics.
- Agnele Sewa presented “The Role of p38-γ in
Myelination and Remyelination.” Mentor: M.
Laura Feltri, MD, professor of biochemistry and neurology.
CLIMB UP and its associated programs are part of
program, directed by Margarita
L. Dubocovich, PhD, senior associate dean for diversity and
inclusion and SUNY Distinguished Professor of pharmacology and
Dental Medicine, Roswell Students Participated
The Aug. 4 event included 26 students from Roswell Park
Comprehensive Cancer Center’s Summer Research Experience
Program in Cancer Science and three students from the UB School of
Dental Medicine’s Student Research Program. The event was
held at the Buffalo Clinical and Translational Research
An undergraduate, with a mentor from the Department of Exercise
and Nutrition Sciences in the School of Public Health and Health
Professions, also participated.