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• N. Oetiker, J. J. León, M. Swihart, K. W. Chen, B. A. Pfeifer, A. Dutta, A. Pliss, A. N. Kuzmin, J. M. Pérez-Donoso, P. N. Prasad, “Unlocking nature's brilliance: using Antarctic extremophile <i>Shewanella baltica</i> to biosynthesize lanthanide-containing nanoparticles with optical up-conversion”, J. Nanobiotechnol. 22, 637 (2024). PDF
• J. J. León, N. Oetiker, N. Torres, N. Bruna, E. Oskolkov, P. D. Lei, A. N. Kuzmin, K. W. Chen, S. Andreadis, B. A. Pfeifer, M. T. Swihart, P. N. Prasad, J. Pérez-Donoso, “Microbial green synthesis of luminescent terbium sulfide nanoparticles using <i>E. Coli</i>: a rare earth element detoxification mechanism”, Microb. Cell. Fact. 23, 248 (2024). PDF
• X. Xu, Y. M. Chang, Y. H. Chen, L. N. Zhou, F. L. Zhang, C. T. Ma, Q. Che, T. J. Zhu, B. A. Pfeifer, G. J. Zhang, D. H. Li, “Biosynthesis of Atypical Angucyclines Unveils New Ring Rearrangement Reactions Catalyzed by Flavoprotein Monooxygenases”, Org. Lett. (2024).
• X. L. Liu, K. Li, J. Yu, C. T. Ma, Q. Che, T. J. Zhu, D. H. Li, B. A. Pfeifer, G. J. Zhang, “Cyclo-diphenylalanine production in<i> Aspergillus</i><i> nidulans</i> through stepwise metabolic engineering”, Metab. Eng. 82, 147-156 (2024).
• B. . A. .. Pfeifer, M. Beitelshees, A. Hill, J. Bassett, C. . H. .. Jones, “Harnessing synthetic biology for advancing RNA therapeutics and vaccine design”, NPJ SYSTEMS BIOLOGY AND APPLICATIONS 9, 60 (2023).
• Y. M. Chang, L. N. Zhou, X. W. Hou, T. J. Zhu, B. A. Pfeifer, D. H. Li, X. X. He, G. J. Zhang, Q. Che, “Microbial Dimerization and Chlorination of Isoflavones by a Takla Makan Desert-Derived Streptomyces sp. HDN154127”, J. Nat. Prod. (2022).
• M. Bhalla, R. Nayerhoda, E. Y. I. Tchalla, A. Abamonte, D. Park, S. R. Simmons, B. A. Pfeifer, E. N. B. Ghanem, “Liposomal Encapsulation of Polysaccharides (LEPS) as an Effective Vaccine Strategy to Protect Aged Hosts Against <i>S. pneumoniae</i> Infection”, Front. Aging 2, 798868 (2021).
• G. Swayambhu, I. Raghavan, B. G. Ravi, B. A. Pfeifer, Z. Q. Wang, “Salicylate Glucoside as a Nontoxic Plant Protectant Alternative to Salicylic Acid”, ACS Agric. Sci. Technol. 1, 515-521 (2021).
• R. Nayerhoda, A. Hill, B. A. Pfeifer, “Liposomal Dual Delivery of Both Polysaccharide and Protein Antigens”, Methods Mol. Biol. 2183, 477-487 (2021).
• R. Q. Qi, A. Hill, B. A. Pfeifer, “A Hybrid Biological-Biomaterial Vector for Antigen Delivery”, Methods Mol. Biol. 2183, 461-475 (2021).
• B. A. Pfeifer, A. Hill, "Vaccine Delivery Technology Methods and Protocols Preface", Methods Mol. Biol. 2183, V-VI (2021).
• A. Hill, M. Beitelshees, B. A. Pfeifer, “Vaccine Delivery and Immune Response Basics”, Methods Mol. Biol. 2183, 1-8 (2021).
• C. D. Bohannon, Z. Ende, W. P. Cao, W. P. Mboko, P. Ranjan, A. Kumar, M. Mishina, S. Amoah, S. Gangappa, S. K. Mittal, J. F. Lovell, A. Garcia-Sastre, B. A. Pfeifer, B. A. Davidson, P. Knight, S. Sambhara, “Influenza Virus Infects and Depletes Activated Adaptive Immune Responders”, Advanced Science 8, 2100693 (2021).
• D. Park, A. Hill, B. A. Pfeifer, “Improving E. coli Bactofection by Expression of Bacteriophage Phi X174 Gene E”, Methods Mol. Biol. 2211, 3-14 (2021).
• W. Walkowski, J. Bassett, M. Bhalla, B. A. Pfeifer, E. N. B. Ghanem, “Intranasal Vaccine Delivery Technology for Respiratory Tract Disease Application with a Special Emphasis on Pneumococcal Disease”, Vaccines 9, 589 (2021).
• G. Swayambhu, M. Bruno, A. M. Gulick, B. A. Pfeifer, “Siderophore natural products as pharmaceutical agents”, Curr. Opin. Biotechnol. 69, 242-251 (2021).
• B. A. Pfeifer, G. J. Zhang, “Editorial overview: Pharmaceutical biotechnology”, Curr. Opin. Biotechnol. 69, VI-VIII (2021).
• R. N. Sun, H. Y. Xu, Y. Y. Feng, X. W. Hou, T. J. Zhu, Q. Che, B. Pfeifer, G. J. Zhang, D. H. Li, “An efficient marker recycling system for sequential gene deletion in a deep sea-derived fungus Acremonium sp. HDN16-126”, Synth. Syst. Biotechnol. 6, 127-133 (2021).
• Y. M. Chang, Q. Che, L. Xing, C. T. Ma, Y. X. Han, T. J. Zhu, B. A. Pfeifer, J. X. Peng, G. J. Zhang, D. H. Li, “Antibacterial p-Terphenyl with a Rare 2,2 '-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086”, J. Nat. Prod. 84, 1226-1231 (2021).
• R. Q. Qi, G. Swayambhu, M. Bruno, G. J. Zhang, B. A. Pfeifer, “Consolidated plasmid Design for Stabilized Heterologous Production of the complex natural product Siderophore Yersiniabactin”, Biotechnol. Prog. 37, e3103 (2021).
• D. Park, G. Swayambhu, T. Lyga, B. A. Pfeifer, “Complex natural product production methods and options”, Synth. Syst. Biotechnol. 6, 1-11 (2021).
• G. Swayambhu, N. Moscatello, G. E. Atilla-Gokcumen, B. A. Pfeifer, “Flux Balance Analysis for Media Optimization and Genetic Targets to Improve Heterologous Siderophore Production”, iScience 23, 101016 (2020).
• R. Nayerhoda, D. Park, C. Jones, E. N. B. Ghanem, B. A. Pfeifer, “Extended Polysaccharide Analysis within the Liposomal Encapsulation of Polysaccharides System”, Materials 13, 3320 (2020).
• A. Jafari, N. Rajabian, G. Zhang, M. A. Mohamed, P. Lei, S. T. Andreadis, B. A. Pfeifer, C. Cheng, “PEGylated Amine-Functionalized Poly(epsilon-caprolactone) for the Delivery of Plasmid DNA”, Materials 13, 898 (2020).
• D. Park, G. Swayambhu, B. A. Pfeifer, “Heterologous biosynthesis as a platform for producing new generation natural products”, Curr. Opin. Biotechnol. 66, 123-130 (2020).
• X. Chen, E. Deng, D. Park, B. A. Pfeifer, N. Dai, H. Lin, “Grafting Activated Graphene Oxide Nanosheets onto Ultrafiltration Membranes Using Polydopamine to Enhance Antifouling Properties”, ACS Appl. Mater. Interfaces 12, 48179-48187 (2020).
• Y. M. Chang, L. Xing, C. X. Sun, S. Liang, T. Liu, X. M. Zhang, T. J. Zhu, B. A. Pfeifer, Q. Che, G. J. Zhang, D. H. Li, “Monacycliones G-K and ent-Gephyromycin A, Angucycline Derivatives from the Marine-Derived Streptomyces sp. HDN15129”, J. Nat. Prod. 83, 2749-2755 (2020).
• X. Y. Liu, K. M. Hua, D. X. Liu, Z. L. Wu, Y. Wang, H. R. Zhang, Z. X. Deng, B. A. Pfeifer, M. Jiang, “Heterologous Biosynthesis of Type II Polyketide Products Using E. coli”, ACS Chemical Biology 15, 1177-1183 (2020).
• M. Beitelshees, A. Hill, Y. Li, M. F. Chen, M. K. Ahmadi, R. J. Smith, S. T. Andreadis, P. Rostami, C. H. Jones, B. A. Pfeifer, “Antigen delivery format variation and formulation stability through use of a hybrid vector”, Vaccine: X 1, 100012 (2019).
• R. Nayerhoda, A. Hill, M. Beitelshees, C. Jones, B. Pfeifer, “Design Variation of a Dual-Antigen Liposomal Vaccine Carrier System”, Materials 12, 2809 (2019).
• S. Ghosh, R. Q. Qi, K. A. Carter, G. J. Zhang, B. A. Pfeifer, J. F. Lovell, “Loading and releasing ciprofloxacin in photoactivatable liposomes”, Biochem. Eng. J. 141, 43-48 (2019).
• M. Beitelshees, A. Hill, P. Rostami, C. H. Jones, B. A. Pfeifer, “A Transition to Targeted or 'Smart' Vaccines: How Understanding Commensal Colonization Can Lead to Selective Vaccination”, Pharm. Med. 32, 95-102 (2018).
• N. Moscatello, G. Swayambhu, C. H. Jones, J. L. Xu, N. Dai, B. A. Pfeifer, “Continuous removal of copper, magnesium, and nickel from industrial wastewater utilizing the natural product yersiniabactin immobilized within a packed-bed column”, Chem. Eng. J. 343, 173-179 (2018).
• M. Beitelshees, A. Hill, C. H. Jones, B. A. Pfeifer, “Phenotypic Variation during Biofilm Formation: Implications for Anti-Biofilm Therapeutic Design”, Materials 11, 1086 (2018).
• A. Hill, M. Beiteishees, B. A. Pfeifer, C. H. Jones, “Standardization of Pneumococcal Biofilm Release to PncO Expression, a Predictive Measurement of Virulence”, Infect. Immun. 86, e00494-18 (2018).
• R. Q. Qi, B. A. Pfeifer, G. J. Zhang, “Engineering Heterologous Production of Salicylate Glucoside and Glycosylated Variants”, Front. Microbiol. 9, 2241 (2018).
• L. Fang, G. J. Zhang, O. El-halfawy, M. Simon, E. D. Brown, B. A. Pfeifer, “Broadened glycosylation patterning of heterologously produced erythromycin”, Biotechnol. Bioeng. 115, 2771-2777 (2018).
• N. Moscatello, B. A. Pfeifer, “Constraint-based metabolic targets for the improved production of heterologous compounds across molecular classification”, AIChE J. 64, 4208-4217 (2018).
• A. B. Hill, M. Beitelshees, R. Nayerhoda, B. A. Pfeifer, C. H. Jones, “Engineering a Next-Generation Glycoconjugate-Like Streptococcus pneumoniae Vaccine”, ACS Infect. Dis. 4, 1553-1563 (2018).
• L. Fang, M. Guell, G. M. Church, B. A. Pfeifer, “Heterologous erythromycin production across strain and plasmid construction”, Biotechnol. Prog. 34, 271-276 (2018).
• X. Y. Liu, D. X. Liu, M. Xu, M. F. Tao, L. Q. Bai, Z. X. Deng, B. A. Pfeifer, M. Jiang, “Reconstitution of Kinamycin Biosynthesis within the Heterologous Host Streptomyces albus J1074”, J. Nat. Prod. 81, 72-77 (2018).
• E. K. Matich, M. Ghafari, E. Camgoz, E. Caliskan, B. A. Pfeifer, B. Z. Haznedaroglu, G. E. Atilla-Gokcumen, “Time-series lipidomic analysis of the oleaginous green microalga species Ettlia oleoabundans under nutrient stress”, Biotechnol. Biofuels 11, 29 (2018).
• C. H. Jones, G. J. Zhang, R. Nayerhoda, M. Beitelshees, A. Hill, P. Rostami, Y. Li, B. A. Davidson, P. Knight, B. A. Pfeifer, “Comprehensive vaccine design for commensal disease progression”, Sci. Adv. 3, e1701797 (2017).
• M. Beitelshees, A. Hill, P. Rostami, C. H. Jones, B. A. Pfeifer, "Pressing Diseases that Represent Promising Targets for Gene Therapy", Discov. Med. 24, 313-322 (2017). abstract
• N. J. Moscatello, B. A. Pfeifer, “Yersiniabactin metal binding characterization and removal of nickel from industrial wastewater”, Biotechnol. Prog. 33, 1548-1554 (2017).
• N. Moscatello, R. Q. Qi, M. K. Ahmadi, B. A. Pfeifer, “Increased Production of Yersiniabactin and an Anthranilate Analog Through Media Optimization”, Biotechnol. Prog. 33, 1193-1200 (2017).
• U. Chitgupi, Y. Li, M. F. Chen, S. Shao, M. Beitelshees, M. J. Tan, S. Neelamegham, B. A. Pfeifer, C. Jones, J. F. Lovell, “Bimodal Targeting Using Sulfonated, Mannosylated PEI for Combined Gene Delivery and Photodynamic Therapy”, Photochem. Photobiol. 93, 600-608 (2017).
• Y. Li, A. Hill, M. Beitelshees, S. Shao, J. F. Lovell, B. A. Davidson, P. R. Knight, A. P. Hakansson, B. A. Pfeifer, C. H. Jones, “Directed vaccination against pneumococcal disease”, Proc. Natl. Acad. Sci. U. S. A. 113, 6898-6903 (2016).
• M. K. Ahmadi, L. Fang, N. Moscatello, B. A. Pfeifer, “E-coli metabolic engineering for gram scale production of a plant-based anti-inflammatory agent”, Metab. Eng. 38, 382-388 (2016).
• M. K. Ahmadi, B. A. Pfeifer, “Improved Heterologous Production of the Nonribosomal Peptide-Polyketide Siderophore Yersiniabactin Through Metabolic Engineering and Induction Optimization”, Biotechnol. Prog. 32, 1412-1417 (2016).
• M. Beitelshees, Y. Li, B. A. Pfeifer, “Enhancing vaccine effectiveness with delivery technology”, Curr. Opin. Biotechnol. 42, 24-29 (2016).
• M. K. Ahmadi, B. A. Pfeifer, “Recent progress in therapeutic natural product biosynthesis using Escherichia coli”, Curr. Opin. Biotechnol. 42, 7-12 (2016).
• B. A. Pfeifer, Y. Tang, “Editorial overview: Pharmaceutical biotechnology: New approaches for dynamic disease targets”, Curr. Opin. Biotechnol. 42, VI-VII (2016).
• E. K. Matich, D. M. Butryn, M. Ghafari, V. del Solar, E. Camgoz, B. A. Pfeifer, D. S. Aga, B. Z. Haznedaroglu, G. E. Atilla-Gokcumen, “Mass spectrometry-based metabolomics of value-added biochemicals from Ettlia oleoabundans”, Algal Res. 19, 146-154 (2016).
• M. K. Ahmadi, M. Ghafari, J. D. Atkinson, B. A. Pfeifer, “A copper removal process for water based upon biosynthesis of yersiniabactin, a metal-binding natural product”, Chem. Eng. J. 306, 772-776 (2016).
• M. K. Ahmadi, S. Fawaz, B. A. Pfeifer, “An aqueous two-phase system to pre-purify a heterologously produced siderophore”, Technology 4, 135-138 (2016).
• Y. Li, M. Beitelshees, L. Fang, A. Hill, M. K. Ahmadi, M. Chen, B. A. Davidson, P. Knight, R. J. Smith, S. T. Andreadis, A. P. Hakansson, C. H. Jones, B. A. Pfeifer, “In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector”, Sci. Adv. 2, e1600264 (2016).
• M. K. Ahmadi, S. Fawaz, L. Fang, Z. P. Yu, B. A. Pfeifer, “Molecular variation of the nonribosomal peptide-polyketide siderophore yersiniabactin through biosynthetic and metabolic engineering”, Biotechnol. Bioeng. 113, 1067-1074 (2016).
• H. R. Zhang, L. Fang, M. S. Osborne, B. A. Pfeifer, “The Continuing Development of E. coli as a Heterologous Host for Complex Natural Product Biosynthesis”, Methods Mol. Biol. 1401, 121-134 (2016).
• A. B. Hi, M. F. Chen, C. K. Chen, B. A. Pfeifer, C. H. Jones, “Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors”, Trends Biotechnol. 34, 91-105 (2016).
• J. Kumpfmuller, K. Methling, L. Fang, B. A. Pfeifer, M. Lalk, T. Schweder, “Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis”, Appl. Microbiol. Biotechnol. 100, 1209-1220 (2016).
• G. J. Zhang, Y. Li, L. Fang, B. A. Pfeifer, “Tailoring pathway modularity in the biosynthesis of erythromycin analogs heterologously engineered in E. coli”, Sci. Adv. 1, e1500077 (2015).
• Y. Li, G. J. Zhang, B. A. Pfeifer, “Current and Emerging Options for Taxol Production”, Adv. Biochem. Eng. Biotechnol. 148, 405-425 (2015).
• C. H. Jones, A. Hill, M. F. Chen, B. A. Pfeifer, "Contemporary Approaches for Nonviral Gene Therapy", Discov. Med. 107, 447-454 (2015). abstract
• M. K. Ahmadi, S. Fawaz, C. H. Jones, G. J. Zhang, B. A. Pfeifer, “Total Biosynthesis and Diverse Applications of the Nonribosomal Peptide-Polyketide Siderophore Yersiniabactin”, Appl. Environ. Microbiol. 81, 5290-5298 (2015).
• C. H. Jones, A. Gollakota, M. F. Chen, T. C. Chung, A. Ravikrishnan, G. J. Zhang, B. A. Pfeifer, “Influence of molecular weight upon mannosylated bio-synthetic hybrids for targeted antigen presenting cell gene delivery”, Biomaterials 58, 103-111 (2015).
• T. C. Chung, C. H. Jones, A. Gollakota, M. K. Ahmadi, S. Rane, G. J. Zhang, B. A. Pfeifer, “Improved Escherichia coli Bactofection and Cytotoxicity by Heterologous Expression of Bacteriophage Phi X174 Lysis Gene E”, Mol. Pharm. 12, 1691-1700 (2015).
• C. H. Jones, M. F. Chen, A. Gollakota, A. Ravikrishnan, G. J. Zhang, S. Lin, M. Tan, C. Cheng, H. Q. Lin, B. A. Pfeifer, “Structure Function Assessment of Mannosylated Poly(beta-amino esters) upon Targeted Antigen Presenting Cell Gene Delivery”, Biomacromolecules 16, 1534-1541 (2015).
• C. H. Jones, C. K. Chen, M. F. Chen, A. Ravikrishnan, H. G. Zhang, A. Gollakota, T. C. Chung, C. Cheng, B. A. Pfeifer, “PEGylated Cationic Polylactides for Hybrid Biosynthetic Gene Delivery”, Mol. Pharm. 12, 846-856 (2015).
• C. H. Jones, M. F. Chen, A. Ravikrishnan, R. Reddinger, G. J. Zhang, A. P. Hakansson, B. A. Pfeifer, “Mannosylated poly(beta-amino esters) for targeted antigen presenting cell immune modulation”, Biomaterials 37, 333-344 (2015).
• C. H. Jones, A. P. Hakansson, B. A. Pfeifer, “Biomaterials at the interface of nano- and micro-scale vector-cellular interactions in genetic vaccine design”, J. Mat. Chem. B 2, 8053-8068 (2014).
• C. H. Jones, A. Ravikrishnan, M. F. Chen, R. Reddinger, M. K. Ahmadi, S. Rane, A. P. Hakansson, B. A. Pfeifer, “Hybrid biosynthetic gene therapy vector development and dual engineering capacity”, Proc. Natl. Acad. Sci. U. S. A. 111, 12360-12365 (2014).
• Y. Li, B. A. Pfeifer, “Heterologous production of plant-derived isoprenoid products in microbes and the application of metabolic engineering and synthetic biology”, Curr. Opin. Plant Biol. 19, 8-13 (2014).
• K. A. Carter, S. Shao, M. I. Hoopes, D. Luo, B. Ahsan, V. M. Grigoryants, W. T. Song, H. Y. Huang, G. J. Zhang, R. K. Pandey, J. Geng, B. A. Pfeifer, C. P. Scholes, J. Ortega, M. Karttunen, J. F. Lovell, “Porphyrin-phospholipid liposomes permeabilized by near-infrared light”, Nat. Commun. 5, 3546 (2014).
• C. K. Chen, Q. Wang, C. H. Jones, Y. Yu, H. G. Zhang, W. C. Law, C. K. Lai, Q. H. Zeng, P. N. Prasad, B. A. Pfeifer, C. Cheng, “Synthesis of pH-Responsive Chitosan Nanocapsules for the Controlled Delivery of Doxorubicin”, Langmuir 30, 4111-4119 (2014).
• M. Jiang, H. R. Zhang, B. A. Pfeifer, “The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli”, J. Vis. Exp. (71), e4346 (2013).
• M. Jiang, H. R. Zhang, S. H. Park, Y. Li, B. A. Pfeifer, “Deoxysugar pathway interchange for erythromycin analogues heterologously produced through Escherichia coli”, Metab. Eng. 20, 92-100 (2013).
• C. K. Chen, C. H. Jones, P. Mistriotis, Y. Yu, X. N. Ma, A. Ravikrishnan, M. Jiang, S. T. Andreadis, B. A. Pfeifer, C. Cheng, “Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery”, Biomaterials 34, 9688-9699 (2013).
• C. H. Jones, S. Rane, E. Patt, A. Ravikrishnan, C. K. Chen, C. Cheng, B. A. Pfeifer, “Polymyxin B Treatment Improves Bactofection Efficacy and Reduces Cytotoxicity”, Mol. Pharm. 10, 4301-4308 (2013).
• C. H. Jones, C. K. Chen, A. Ravikrishnan, S. Rane, B. A. Pfeifer, “Overcoming Nonviral Gene Delivery Barriers: Perspective and Future”, Mol. Pharm. 10, 4082-4098 (2013).
• M. Jiang, B. A. Pfeifer, “Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli”, Metab. Eng. 19, 42-49 (2013).
• M. Jiang, L. Fang, B. A. Pfeifer, “Improved heterologous erythromycin A production through expression plasmid re-design”, Biotechnol. Prog. 29, 862-869 (2013).
• C. H. Jones, C. K. Chen, M. Jiang, L. Fang, C. Cheng, B. A. Pfeifer, “Synthesis of Cationic Polylactides with Tunable Charge Densities as Nanocarriers for Effective Gene Delivery”, Mol. Pharm. 10, 1138-1145 (2013).
• J. Rucker, J. Paul, B. A. Pfeifer, K. Lee, “Engineering E. coli for triglyceride accumulation through native and heterologous metabolic reactions”, Appl. Microbiol. Biotechnol. 97, 2753-2759 (2013).
• M. Jiang, G. Stephanopoulos, B. A. Pfeifer, “Downstream reactions and engineering in the microbially reconstituted pathway for Taxol”, Appl. Microbiol. Biotechnol. 94, 841-849 (2012).
• M. Jiang, G. Stephanopoulos, B. A. Pfeifer, “Toward Biosynthetic Design and Implementation of Escherichia coli-Derived Paclitaxel and Other Heterologous Polyisoprene Compounds”, Appl. Environ. Microbiol. 78, 2497-2504 (2012).
• J. W. Armando, B. A. Boghigian, B. A. Pfeifer, “LC-MS/MS quantification of short-chain acyl-CoA's in Escherichia coli demonstrates versatile propionyl-CoA synthetase substrate specificity”, Lett. Appl. Microbiol. 54, 140-148 (2012).
• H. Zhang, B. A. Boghigian, J. Armando, B. A. Pfeifer, “Methods and options for the heterologous production of complex natural products”, Nat. Prod. Rep. 28, 125-151 (2011).
• B. A. Boghigian, H. Zhang, B. A. Pfeifer, “Multi-Factorial Engineering of Heterologous Polyketide Production in Escherichia coli Reveals Complex Pathway Interactions”, Biotechnol. Bioeng. 108, 1360-1371 (2011).
• B. A. Boghigian, K. Lee, B. A. Pfeifer, “Computational analysis of phenotypic space in heterologous polyketide biosynthesis-Applications to Escherichia coli, Bacillus subtilis, and Saccharomyces cerevisiae”, J. Theor. Biol. 262, 197-207 (2010).
• H. Zhang, B. A. Boghigian, B. A. Pfeifer, “Investigating the Role of Native Propionyl-CoA and Methylmalonyl-CoA Metabolism on Heterologous Polyketide Production in Escherichia coli”, Biotechnol. Bioeng. 105, 567-573 (2010).
• B. A. Boghigian, G. Seth, R. Kiss, B. A. Pfeifer, “Metabolic flux analysis and pharmaceutical production”, Metab. Eng. 12, 81-95 (2010).
• B. A. Boghigian, H. Shi, K. Lee, B. A. Pfeifer, “Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design”, BMC Syst. Biol. 4, 49 (2010).
• J. Wu, B. A. Boghigian, M. Myint, H. Zhang, S. Zhang, B. A. Pfeifer, “Construction and performance of heterologous polyketide-producing K-12-and B-derived Escherichia coli”, Lett. Appl. Microbiol. 51, 196-204 (2010).
• P. K. Ajikumar, W. H. Xiao, K. E. J. Tyo, Y. Wang, F. Simeon, E. Leonard, O. Mucha, T. H. Phon, B. Pfeifer, G. Stephanopoulos, “Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli”, Science 330, 70-74 (2010).
• H. Zhang, Y. Wang, J. Q. Wu, K. Skalina, B. A. Pfeifer, “Complete Biosynthesis of Erythromycin A and Designed Analogs Using E. coli as a Heterologous Host”, Chem. Biol. 17, 1232-1240 (2010).
• H. Zhang, Y. Wang, B. Boghigian, B. A. Pfeifer, “Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli”, Microb. Biotechnol. 2, 390-394 (2009).
• M. Pistorino, B. A. Pfeifer, “Efficient Experimental Design and Micro-Scale Medium Enhancement of 6-deoxyerythronolide B Production through Escherichia coli”, Biotechnol. Prog. 25, 1364-1371 (2009).
• Y. Wang, B. A. Pfeifer, “6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli”, Metab. Eng. 10, 33-38 (2008).
• M. Pistorino, B. A. Pfeifer, “Polyketide analysis using mass spectrometry, evaporative light scattering, and charged aerosol detector systems”, Anal. Bioanal. Chem. 390, 1189-1193 (2008).
• H. Zhang, Y. Wang, B. A. Pfeifer, “Bacterial hosts for natural product production”, Mol. Pharm. 5, 212-225 (2008).
• B. Pfeifer, “Natural products and production systems: Opening comments”, Mol. Pharm. 5, 165-166 (2008).
• S. Parsa, Y. Wang, J. Fuller, R. Langer, B. A. Pfeifer, “A comparison between polymeric microsphere and bacterial vectors for macrophage P388D1 gene delivery”, Pharm. Res. 25, 1202-1208 (2008).
• B. A. Boghigian, B. A. Pfeifer, “Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli”, Biotechnol. Lett. 30, 1323-1330 (2008).
• S. Parsa, Y. Wang, K. Rines, B. A. Pfeifer, “A high-throughput comparison of recombinant gene expression parameters for E-coli-mediated gene transfer to P388D1 macrophage cells”, J. Biotechnol. 137, 59-64 (2008).
• S. Parsa, B. Pfeifer, “Engineering bacterial vectors for delivery of genes and proteins to antigen-presenting cells”, Mol. Pharm. 4, 4-17 (2007).
• Y. Wang, B. A. Boghigian, B. A. Pfeifer, “Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene”, Appl. Microbiol. Biotechnol. 77, 367-373 (2007).
• B. A. Pfeifer, J. A. Burdick, S. R. Little, R. Langer, “Poly(ester-anhydride): poly(beta-amino ester) micro- and nanospheres: DNA encapsulation and cellular transfection”, Int. J. Pharm. 304, 210-219 (2005).