Eaton Lattman


photo of Eaton Lattman

Eaton Lattman


Eaton Lattman


Research Topics

X-ray free-electron lasers in biological scattering; protein folding; development and improvement of methods in protein crystallography

Contact Information

Hauptman-Woodward Medical Research Institute

700 Ellicott Street

Buffalo NY, 14203

Phone: (716) 898-8612




  • Warner E. Love, Wayne A. Hendrickson, Jon R. Herriott, Eaton E. Lattman and G. Lewis McCorkle. "Compact, Versatile X-ray Collimator with Adjustable Pinholes," Rev. Sci. Instrum. 36, 1655-1658, (1964).
  • Warner E. Love and Eaton Lattman. "Crystalline Hemoglobin from the Marine Annelid Amphitrite Ornata," Hvalradets Skrifter 48, 110-111, (1965).
  • Wayne A. Hendrickson and Eaton E. Lattman. "Representation of Phase Probability Distributions for Simplified Combination of Independent Phase Information," Acta Crystallogr. B26, 136-143, (1970).
  • Eaton E. Lattman and Warner E. Love. "A Rotational Search Procedure for Detecting a Known Molecule in a Crystal," Acta Crystallogr. B26, 1854-1857, (1970).
  • Eaton E. Lattman, Clive E. Nockolds, Robert H. Kretsinger and Warner E. Love. "The Structure of Yellow Fin Tuna Metmyoglobin at 6 Angstroms Resolution," J. Mol. Biol. 60, 271-277, (1971).
  • Eaton E. Lattman. "Optimal Sampling of the Rotation Function," Acta Crystallogr. B28, 1065-1068, (1972).
  • Eaton E. Lattman. "The Mean Figure of Merit of a Difference Fourier Synthesis," Acta Crystallogr. A28, 220, (1972).
  •  Michael Schmid, Eaton Lattman and Jon Herriott. "The Structure of Bovine Carboxypeptidase B: Results at 5.5 A Resolution," J. Mol. Biol. 84, 97-101, (1974).
  • P.M. Colman, O. Epp, H. Fehlhammer, M. Schiffer, E.E. Lattman and T.A.Jones. "X-Ray Studies on Antibody Fragments," FEBS Lett. 44(2), 194-199, (1974).
  • H. Fehlhammer, M. Schiffer, O. Epp, P.M. Colman, E.E. Lattman, P. Schwager and W. Steigemann. "The Structure Determination of the Variable Portion of the Bence-Jones Protein AU," Biophys. Struct. Mech. 1, 139-146, (1975).
  • Barry C. Wishner, Keith B. Ward, Eaton E. Lattman and Warner E. Love. "Structure of Sickle Cell Deoxy-hemoglobin at 5 A Resolution," J. Mol. Biol. 98, 179-194, (1975).
  • K.B. Ward, B.C. Wishner, E.E. Lattman and W.E. Love. "Structure of Deoxy HbA Crystals from Polyethylene Glycol Solutions," J. Mol. Biol. 98, 161, (1975).
  • Otto Epp, Eaton E. Lattman, Marianne Schiffer, Robert Huber and Walter Palm. "The Molecular Structure of a Dimer Composed of the Bence-Jones Protein REI at 2.0 Resolution," Biochemistry 14(22), 4943-4952, (1975).
  • C. Thaxton and E. Lattman. "Minimizing Thermal Gradient Problems During Precession Photography of Protein Crystals," J. Appl. Cryst. 10, 60-61, (1977).
  • K.W. Adolph, D.L.D. Caspar, C.J. Hollinshead, E.E. Lattman, W.C. Phillips and W.T. Murakami. "Polyoma Virion and Capsid Crystal Structures," Science 203, 1117-1119, (1979).
  • G.N. Phillips, Jr., E.E. Lattman, P. Cummins, K.Y. Lee and C. Cohen. "Crystal Structure and Molecular Interactions of Tropomyosin," Nature 278, 413-417, (1979).
  • Eaton E. Lattman. "Simian Virus 40 Crystals," Science 208, 1048-1050, (1980).
  • Eaton Lattman, Rufus Burlingame, Chris Hatch and Evangelos N. Moudrianakis. "Crystallization of the Histone Tetramer (H3-H4)2," Science 216, 1016-1018, (1982).
  • Magnus, K.A. and Lattman, E.E. "Histones H3 and H2a are Homologous to the Lambda Repressor and Cro Proteins in 22 Residue Segments Implicated in DNA Binding," Biochem. Int. 7, 557-568, (1983).
  • Hendrickson, W.A., Strandberg, B.E., Liljas, A, Amzel, L.M., Lattman, E.E. "True Identity of a Diffraction Pattern Attributed to Valyl tRNA," Nature 303, 193, (1983).
  • Ki, P.F., Lattman, E.E. and Kishimoto, Y. "Structure and Function of Urodele Myelin Lacking Alpha-Hydroxy Fatty Acid-Containing Galactosphingolipids: Slow Nerve Conduction and Unusual Myelin Thickness," Brain Res. 345, 19-24, (1985).
  • Magnus, K.A., Lattman, E.E., Sato, M. and Pollard, T.D. "Crystallization of Acanthamoeba Profilin-I," J. Biol. Chem. 261,13360-13361, (1986).
  • P.J. Loll, A.K. Meeker, D. Shortle, M. Pease and E.E. Lattman. "Crystallization and Preliminary X-ray Analysis of a Quadruple Mutant of Staphylococcal Nuclease," J. Biol. Chem. 263, 18190-2, (1988).
  • Eaton Edward Lattman, "Rapid Calculation of the Solution Scattering Profile from a Macromolecule of Known Structure," Proteins: Struc. Funct. Genet. 5(2), 249-155, (1989).
  • P.J. Loll and E.E. Lattman. "Structure of the Complex of Staphyloccal Nuclease with Deoxythymidine 3'-5'-bisphosphate and Calcium Ion Refined at 1.65A," Proteins: Struc. Funct. Genet. 5, 183-201, (1989).
  • Eaton E. Lattman. "Calculation of the Point-by-point Error in Protein Crystallographic Electron Density Functions," Acta Crystallogr. A46, 628-630, (1990).
  • Patrick J. Loll, Robert A. Sparks and Eaton E. Lattman. "An Omega Scan Artifact Observed in Nicolet P3F Diffractometers," J. Appl. Cryst. 23, 212-124, (1990).
  • Patrick J. Loll and Eaton Edward Lattman. "Active Site Mutant Glu-43->Asp in Staphylococcal Nuclease Displays Non-local Structural Changes," Biochemistry 29, 6866-6873, (1990).
  • Karen A. Magnus, Eaton E. Lattman, Anne Volbeda and Wim G.J. Hol. "Hexamers of Subunit II from Limulus Hemocyanin (a 48-mer) Have the Same Quaternary Structure as Whole Panilurus Hemocyanin Molecules," Proteins: Struc. Funct. Genet. 9(4), 240-247, (1991).
  • Michael J. Behe, Eaton E. Lattman, and George D. Rose. "The Protein Folding Problem: the Native Fold Determines Packing, but Does Packing Determine the Native Fold?" PNAS 88.4195-4199, (1991).
  • Francine Smith, Eaton Lattman and Charles Carter. "The Mutant ß99 Asp->Tyr Stabilizes Y, A New, Composite Quaternary State of Human Hemoglobin," Proteins: Struc. Funct. Genet. 10(2), 81-91, (1991).
  • Wesley E. Stites, Apostolos Gittis, David Shortle and Eaton E. Lattman. "In a Staphylococcal Nuclease Mutant the Side Chain of a Lysine Replacing Valine 66 is Fully Buried in the Hydrophobic Core," J. Mol. Biol. 221, 7-14, (1991).
  • Lisa J. Keefe, Eaton E. Lattman, Marc Chevrier, Cathy Wolkow, Amina Woods, and Robert J. Cotter. "Resolution of a Protein Sequence Ambiguity by X-ray Crystallographic and Mass Spectrometric Methods," J. Appl. Cryst. 25, 205-210. (1992).
  • David J. Weber, Apostolos Gittis, Gregory P. Mullen, Chitrananda Abeygunawardana, Eaton E. Lattman, and Albert S. Mildvan. "NMR Docking of a Substrate into the X-ray Structure of Staphylococcal Nuclease," Proteins: Struc. Funct. Genet. 13(4), 275-287, (1992).
  • Lisa J. Keefe, John Sondek, David Shortle, and Eaton Lattman. “The α Aneurism: A Structural Motif Revealed in an Insertion Mutant of Staphylococcal Nuclease,” PNAS 90, 3275-3279, (1993).
  • Eaton E. Lattman and George D. Rose. “Protein Folding - What’s the Question?” PNAS 90, 439-441, (1993).
  • Apostolos G. Gittis, Wesley E. Stites, and Eaton E. Lattman. “The Phase Transition between a Compact Denatured State and a Random Coil State in Staphylococcal Nuclease is First-Order,” J. Mol. Biol. 232(3), 718-724, (1993).
  • David J. Weber, Engin H. Serpersu, Apostolos G. Gittis, Eaton E. Lattman and Albert S. Mildvan. “NMR Docking of the Competitive Inhibitor Thymidine 3’-5’-Diphosphate Into the Xray Structure of Staphylococcal Nuclease,” Proteins: Struc. Funct. Genet. 17(1), 20-35, (1993).
  • Valda K. Vinson, Sharon J. Archer, Eaton E. Lattman, Thomas D. Pollard, Dennis A. Torchia. “Three Dimensional Solution Structure of Acanthamoemba Profilin-I,” J. Cell Biol. 122(6), 1277-1283, (1993).
  • Lisa J. Keefe, Stephen Quirk, Apostolos Gittis, John Sondek, and Eaton Lattman. “Accommodation of Insertion Mutations on the Surface and in the Interior of Staphylococcal Nuclease,” Protein Sci. 3, 391-401, (1994).
  • Eaton E. Lattman, Klaus Fiebig, and Ken A. Dill. “Modeling Compact, Denatured States of Proteins,” Biochemistry 33, 6158-6166, (1994).
  • S.C. Almo, T.D. Pollard, M. Way, E.E. Lattman. “Purification, Characterization and Crystallization of Acanthamoeba Profilin Expressed in Escherichia coli," J. Mol. Biol. 236, 950-952, (1994).
  • Eaton Lattman. “Protein Crystallography for All,” Proteins: Struc. Funct. Genet. 18(2), 103-106, (1994).
  • Andrew Libson, Apostolos Gittis, Eaton Lattman. “The Crystal Structures of Binary Ca2++ and pdTp Complexes and the Ternary Complex of the Asp21->Glu Mutant of Staphylococcal Nuclease,” Biochemistry 33(26), 8007-16, (1994).
  • Alexander A. Federov, Karen. A. Magnus, Henni Graupe, Eaton E. Lattman, Thomas D. Pollard, and Steven C. Almo. “X-ray Structures of Isoforms of the Actin Binding Protein Profilin that Differ in Their Affinity for Polyphosphoinositides," PNAS 91, 8636-8640, (1994).
  • Yuri V. Griko, Apostolos Gittis, Eaton E. Lattman , and Peter Privalov. “Residual Structure in a Staphylococcal Nuclease Fragment: Is it a Molten Globule and is its Unfolding a First Order Phase Transition?” J. Mol. Biol. 243, 93-99, (1994).
  • Patrick J. Loll, Stephen Quirk, E.E. Lattman and R. Michael Garavito. “X-ray Crystal Structures of Staphylococcal Nuclease Complexed with the Competitive Inhibitor Cobalt(II) and Nucleotide,” Biochemistry 34(13), 4316-4324, (1995).
  • Susan M. Green, Apostolos G. Gittis, Alan K. Meeker, and Eaton E. Lattman. “One-step Evolution of a Dimer from a Monomeric Protein,” Nat. Struct. Biol. 2, 746-751, (1995).
  • Andrew M. Libson, Apostolos G. Gittis, Ivan E. Collier, Barry L. Marmer, Gregory I. Goldberg, and Eaton E. Lattman. “Crystal Structure of the Hemopexin-like C-terminal Domain of Gelatinase A,” Nat. Struct. Biol. 2, 938-942, (1995).
  • Shonda Leonard, Apostolos Gittis, Eugene Petrella, Thomas D. Pollard, Eaton E. Lattman. “Crystal Structure of the Actin binding Protein Actophorin from Acanthamoeba," Nat. Struct. Biol. 4, 369-373, (1997).
  • Bertrand García-Moreno E., John J. Dwyer, Apostolos G. Gittis, Eaton E. Lattman, Daniel S. Spenser, Wesley. E. Stites. "Experimental Measurement of the Effective Dielectric in the Hydrophobic Core of a Proteins," Biophys. Chem. 64, 211-224, (1997).
  • Shenping Liu, Alexander A. Federov, Thomas D. Pollard, Eaton Edward Lattman, Steven Almo, and Karen Magnus. “Crystal Packing Induces a Conformational Change in Profilin-I from Acanthamoeba castellanii," J. Struct. Biol. 123, 22-29, (1998).
  • Graeme L. Conn, David E. Draper, Eaton E. Lattman, and Apostolos G. Gittis. “Crystal Structure of a Conserved Ribosomal Protein-RNA Complex,” Science 284, 1171-74, (1999).
  • Duc Nguyen, Apostolos Gittis, Eaton E. Lattman. “An Eight Residue Duplication in Staphylococcal Nuclease Adopts a Different Conformation: A Model for Evolutionary Change,” Proteins, 15, 465-73, (2000).
  • Eaton E. Lattman. “Molecular structures from femtosecond x-ray pulses.” .Proc. Natl. Acad. Sci. 98, 6535-6 (2001).
  • John J. Dwyer, Apostolos G. Gittis, Daniel Karp, Eaton Lattman David S. Spencer, Wesley E. Stites, Bertrand Garcia-Moreno E. “High apparent dielectric constants in the interior of a protein reflect water penetration.” Biophys J. 79, 1610-20, (2000).
  • Graeme L. Conn, Apostolos G. Gittis, Eaton E. Lattman, Vinod K. Misra, David E. .Draper. “A Compact RNA Tertiary Structure Contains a Buried Backbone-K+ Complex.” J. Mol. Biol. 318, 963-973, (2002).
  • Carolyn A. Fitch, Daniel A. Karp, Kelly K. Lee. Wesley E. Stites, Eaton E. Lattman and Bertrand García-Moreno E “Experimental pKa values of buried residues: analysis with continuum methods and role of water penetration.” Biophys. J. 82, 3289-3304, (2002).
  • Duc Nguyen, R. Leila Reynald, Apostolos Gittis, and Eaton Lattman. “X-ray and Thermodynamic Studies of Staphylococcal Nuclease Variants I92E and K92K: Insights into Polarity of the Protein Interior. J. Mol. Biol. 341(2), 565-574, (2004).
  • Dohm, J. A., Hsu, M. H., Hwu, J. R., Huang, R. C., Moudrianakis, E. N., Lattman, E. E. & Gittis, A. G.. Influence of ions, hydration, and the transcriptional inhibitor P4N on the conformations of the Sp1 binding site. J Mol Biol 349, 731-44, (2005).
  • Anna Damjanovic , Bertrand Garcia-Moreno, Eaton E. Lattman, and Angel Garcia..Molecular dynamics study of hydration of the protein interior. Comp. Phys. Comm. 169 (1-3): 126-129, (2005)
  • Anna Damjanovic,, Bertrand Garcia-Moreno, Eaton E. Lattman and Angel E. Garcia. Molecular dynamics study of water penetration in staphylococcal nuclease. Proteins. 60,443-449, (2005).
  • Jay L. Jeong, Eaton E. Lattman, and Gregory S. Chirikjian. A method for finding candidate conformations for molecular replacement using relative rotation between domains of a known structure. Acta Cryst. D 62, 398-409 (2006).
  • Eaton Lattman. Weighing The Need To Accommodate Women in Physics. Physics Today 60, 12-12, (2007).
  • Eaton Lattman. Expanding the Discussion on IRBs in the Humanities and Social and Behavioral Sciences. AAHRP Advance 5(2), 7. (2008).
  • Lattman EE and DeRosier DJ.. Why phase errors affect the electron-density function more than amplitude errors. Acta Cryst. A64, 341-344 (2008).
  • Eaton Lattman. The Planck length as the dimension of a transient black hole. Eur J. Phys. 30, L41-L42, (2009).
  • Jan Hoh, William Heinz, Jeffrey Werbin, Eaton Lattman. Computing spatial information from Fourier coefficient distributions. J. Memb. Biol. 241(2), 59-68, (2011).
  • Sol Gruner and Eaton Lattman. Biostructural Science Inspired by Next-generation X-ray Sources. Ann. Rev. Bioph. 44, 33-51, (2015).
  • Eaton Lattman. XFELs in the Study of Biological Structure. Cern Courier, March, 2015.
  • A. Aquila, A. Barty, C. Bostedt, S. Boutet, G. Carini, D. dePonte, P. Drell, S. Doniach, K. H. Downing, T. Earnest, H. Elmlund, V. Elser, M. Gühr, J. Hajdu, J. Hastings, S. P. Hau-Riege,Z. Huang, E. E. Lattman, F. R. N. C. Maia, S. Marchesini, A. Ourmazd, C. Pellegrini, R. Santra, I. Schlichting, C. Schroer, J. C. H. Spence, I. A. Vartanyants, S. Wakatsuki, W. I. Weis and G. J. Williams. The Linac Coherent Light Source Single Particle Road Map. Structural Dynamics 2 041701 (2015); doi: 10.1063/1.4918726.

Book Chapters, Reviews and Miscellaneous

  • Warner E. Love, Wayne A. Hendrickson, Peter A. Klock, Eaton E. Lattman, Eduardo A. Padlan and Keith B. Ward. "The Structure of Lamprey and Bloodworm Hemoglobins in Relation to Their Structure and Function," Cold Spring Harbor Symposia on Quantitative Biology XXXVI, 349-357, (1972).
  • Eaton E. Lattman. "Optimal Sampling of the Rotation Function" in The Molecular Replacement Method, 179-183, M. Rossmann, ed., Gordon and Breach, New York City, (1972).
  • Warner E. Love and Eaton Lattman. "Protein Structure in Relation to Evolution and Function" in Transactions of the American Crystallographic Association IX, 133-140, W. Love and E. Lattman, eds., ACA, New York City, (1972).
  • Eaton E. Lattman and L. Mario Amzel. "Structure Determination of Biological Macromolecules Using X-Ray Diffraction Analysis" in Methods of Experimental Physics 20, 229-297, G. Ehrenstein and H. Lecar, eds., Academic Press, New York, (1982).
  • Lattman, E.E. "Crystallography: Polyoma Virus and Influenza Virus," in Physics News in 1983, P. Schewe, ed., American Institute of Physics, New York, pp. 54-57, (1983).
  • Eaton E. Lattman. "Use of the Rotation and Translation Functions," Methods Enzymol. 115B, 55-77, (1985).
  • E.E. Lattman. "X-ray Microscopy in the Study of Biological Structure: A Prospective View," in X-ray Microscopy II (Springer series in Optical Science Vol. 56), pp. 384-390, D. Sayre, M.R. Howells, J. Kirz and H. Rarback, eds., Springer-Verlag, Heidelberg, New York (1988).
  • Eaton E. Lattman. “Small-angle X-ray Scattering Studies of Protein Folding.” Curr. Opin. Struct. Biol. 4, 87-92, (1994).
  • Thomas Pollard, Steven Almo, Stephen Quirk, Valda Vinson, and Eaton Lattman. “Structure of Actin-binding Proteins: Insights about Function at Atomic Resolution.” Annu. Rev. Cell Biol., 10, 207-49, (1994).
  • Apostolos Gittis, Wesley Stites, and Eaton Lattman. “A First-Order Phase Transition Between a Compact Denatured State and a Random Coil State in Staphylococcal Nuclease,” in Statistical Mechanics, Protein Structure, and Protein Substrate Interactions, pp. 39-47, S. Doniach, ed., Plenum Press, New York, (1994).
  • Reggie Aurora, Trevor Creamer, and Eaton E. Lattman. “1996 Johns Hopkins Protein Folding Meeting.” Proteins: Struc. Funct. Genet. 25, R1-R4, (1996).
  • Joël Janin and Eaton Lattman. “Molecular systematics in 3D: The classification of protein structures – Paris, April 9-11, 1996.” Proteins: Struc. Funct. Genet. 25, R1-R2, (1996).
  • Eaton E. Lattman. “Why are protein crystallographic R-values so high?” Proteins: Struc. Funct. Genet. 25, R1-R2, 1996).
  • Eaton E. Lattman and David E. Draper. “Review of the sixth annual johns hopkins folding meeting.” Proteins: Struc. Funct. Genet. 15, 237-242, (2002).
  • Eaton Lattman. The state of the protein structure initiative Proteins: Struc. Funct. Bioinf. 54(4). 611-615,(2004).
  • Eaton E. Lattman and Patrick J. Loll. "X-ray Crystallography: A Concise Guide." Johns Hopkins Press: Baltimore, MD. (2008).
  • Eaton Lattman. Remembrance of David Sayre. ACA Reflexions, Number 2, (2012).