Stelios Andreadis

PhD

Stelios Andreadis

PhD

Stelios Andreadis

PhD

SUNY Distinguished Professor

Director - Cell, Gene and Tissue Engineering Center

Department of Chemical and Biological Engineering

School of Engineering and Applied Sciences

Research Topics

Stem cells for vascular tissue engineering; signaling pathways in cell-cell adhesion and wound healing; lentiviral vectors and lentiviral microarrays for high-throughput gene expression analysis and gene discovery

Contact Information

908 Furnas Hall

Buffalo NY, 14260

Phone: (716) 645-1202

sandread@buffalo.edu

Publications

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P. Mehrotra, J. Jablonski, J. Toftegaard, Y. L. Zhang, S. Shahini, J. M. Wang, C. W. Hung, R. Ellis, G. Kayal, N. Rajabian, S. Liu, K. C. S. Roballo, S. B. Udin, S. T. Andreadis, K. E. Personius, “Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury”, Nat. Commun. 15, 9218 (2024).
J. J. León, N. Oetiker, N. Torres, N. Bruna, E. Oskolkov, P. D. Lei, A. N. Kuzmin, K. W. Chen, S. Andreadis, B. A. Pfeifer, M. T. Swihart, P. N. Prasad, J. Pérez-Donoso, “Microbial green synthesis of luminescent terbium sulfide nanoparticles using <i>E. Coli</i>: a rare earth element detoxification mechanism”, Microb. Cell. Fact. 23, 248 (2024). PDF
A. K. Podder, M. A. Mohamed, R. A. Seidman, G. Tseropoulos, J. J. Polanco, P. Lei, F. J. Sim, S. T. Andreadis, “Injectable shear-thinning hydrogels promote oligodendrocyte progenitor cell survival and remyelination in the central nervous system”, Sci. Adv. 10, eadk9918 (2024).
S. E. Cassel, B. M. Huntington, W. Chen, P. Lei, S. T. Andreadis, A. M. Kloxin, “Dynamic reporters for probing real-time activation of human fibroblasts from single cells to populations”, APL Bioeng. 8, 026127 (2024).
G. Tseropoulos, P. Mehrotra, A. K. Podder, E. Wilson, Y. L. Zhang, J. M. Wang, A. Koontz, N. P. Gao, R. Gunawan, S. Liu, L. M. Feltri, M. E. Bronner, S. T. Andreadis, “Immobilized NRG1 Accelerates Neural Crest like Cell Differentiation Toward Functional Schwann Cells Through Sustained Erk1/2 Activation and YAP/TAZ Nuclear Translocation”, Advanced Science (2024).
N. Esmaeili, T. Alebrahim, M. A. Mohamed, S. T. Andreadis, H. Q. Lin, “Deep eutectic solvent-inspired supramolecular polymer networks: Unexpected absence of CO2 affinity”, J. Membr. Sci. 705, 122895 (2024).
A. Das, R. J. Smith, S. T. Andreadis, “Harnessing the potential of monocytes/macrophages to regenerate tissue-engineered vascular grafts”, Cardiovasc. Res. (2024).
D. Choudhury, N. Rong, H. V. S. Kumar, S. Swedick, R. Z. Samuel, P. Mehrotra, J. Toftegaard, N. Rajabian, R. Thiyagarajan, A. K. Podder, Y. L. Wu, S. Shahini, K. L. Seldeen, B. Troen, P. Lei, S. T. Andreadis, “Proline restores mitochondrial function and reverses aging hallmarks in senescent cells”, Cell Reports 43, 113738 (2024).
K. Nam, H. T. dos Santos, F. Maslow, T. Small, R. Z. Samuel, P. Lei, S. T. Andreadis, O. J. Baker, “Fibrin hydrogels fortified with FGF-7/10 and laminin-1 peptides promote regeneration of irradiated salivary glands”, Acta Biomater. 172, 147-158 (2023).
Y. Y. Liu, P. Lei, R. Z. Samuel, A. M. Kashyap, T. Groth, W. Bshara, S. Neelamegham, S. T. Andreadis, “Cadherin-11 increases tumor cell proliferation and metastatic potential via Wnt pathway activation”, Mol. Oncol. (2023).
N. Rajabian, I. Ikhapoh, S. Shahini, D. Choudhury, R. Thiyagarajan, A. Shahini, J. Kulczyk, K. Breed, S. Saha, M. A. Mohamed, S. B. Udin, A. Stablewski, K. Seldeen, B. R. Troen, K. Personius, S. T. Andreadis, “Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle”, Nat. Commun. 14, 886 (2023).
M. A. Mohamed, C. L. Rumsey, M. Trebbin, S. T. Andreadis, “Multifunctional Polyurethane Networks Combining Strength, Toughness, and Fast Autonomous Self-Healing via the Synergy of Multiple Dynamic Bonds”, Chem. Mat. (2023).
F. Hemmati, A. Akinpelu, J. Y. Song, F. Amiri, A. McDaniel, C. McMurray, A. Afthinos, S. T. Andreadis, A. V. Aitken, V. C. Biancardi, S. Gerecht, P. Mistriotis, “Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement”, Advanced Science (2023).
N. Rajabian, D. Choudhury, I. Ikhapoh, S. Saha, A. S. Kalyankar, P. Mehrotra, A. Shahini, K. Breed, S. T. Andreadis, “Reversine ameliorates hallmarks of cellular senescence in human skeletal myoblasts via reactivation of autophagy”, Aging Cell 22 (2023).
P. Mehrotra, I. Ikhapoh, P. D. Lei, G. Tseropoulos, Y. L. Zhang, J. M. Wang, S. Liu, M. E. Bronner, S. T. Andreadis, “Wnt/BMP Mediated Metabolic Reprogramming Preserves Multipotency of Neural Crest-Like Stem Cells”, Stem Cells 41, 287-305 (2023).
M. A. Mohamed, L. Y. Yan, A. Shahini, N. Rajabian, A. Jafari, S. T. Andreadis, Y. Wu, C. Cheng, “Well-Defined pH-Responsive Self-Assembled Block Copolymers for the Effective Codelivery of Doxorubicin and Antisense Oligonucleotide to Breast Cancer Cells”, ACS Appl. Bio Mater. 5, 4779-4792 (2022).
D. Choudhury, N. Rong, I. Ikhapoh, N. Rajabian, G. Tseropoulos, Y. L. Wu, P. Mehrotra, R. Thiyagarajan, A. Shahini, K. L. Seldeen, B. R. Troen, P. Lei, S. T. Andreadis, “Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells”, Cell Reports 41, 111744 (2022).
B. Nasiri, T. Yi, Y. L. Wu, R. J. Smith, A. K. Podder, C. K. Breuer, S. T. Andreadis, “Monocyte Recruitment for Vascular Tissue Regeneration”, Adv. Healthc. Mater. 11 (2022).
A. K. Podder, M. A. Mohamed, G. Tseropoulos, B. Nasiri, S. T. Andreadis, “Engineering Nanofiber Scaffolds with Biomimetic Cues for Differentiation of Skin-Derived Neural Crest-like Stem Cells to Schwann Cells”, Int. J. Mol. Sci. 23, 10834 (2022).
K. Nam, H. T. dos Santos, F. Maslow, B. G. Trump, P. Lei, S. T. Andreadis, O. J. Baker, “Laminin-1 Peptides Conjugated to Fibrin Hydrogels Promote Salivary Gland Regeneration in Irradiated Mouse Submandibular Glands”, Front. Bioeng. Biotechnol. 9, 729180 (2021).
A. Shahini, N. Rajabian, D. Choudhury, S. Shahini, K. Vydiam, T. Nguyen, J. Kulczyk, T. Santarelli, I. Ikhapoh, Y. L. Zhang, J. M. Wang, S. Liu, A. Stablewski, R. Thiyagarajan, K. Seldeen, B. R. Troen, J. Peirick, P. Lei, S. T. Andreadis, “Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo”, Sci. Adv. 7, eabe5671 (2021).
A. Y. Wang, S. M. Boroujeni, P. J. Schneider, L. B. Christie, K. A. Mancuso, S. T. Andreadis, K. W. Oh, “An Integrated Centrifugal Degassed PDMS-Based Microfluidic Device for Serial Dilution”, Micromachines 12, 482 (2021).
K. L. Seldeen, A. Shahini, R. Thiyagarajan, Y. Redae, M. Leiker, N. Rajabian, A. Dynka, S. T. Andreadis, B. R. Troen, “Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors”, Nutrition 87-88, 111189 (2021).
N. Anandakrishnan, H. Ye, Z. P. Guo, Z. W. Chen, K. I. Mentkowski, J. K. Lang, N. Rajabian, S. T. Andreadis, Z. Ma, J. A. Spernyak, J. F. Lovell, D. P. Wang, J. Xia, C. Zhou, R. G. Zhao, “Fast Stereolithography Printing of Large-Scale Biocompatible Hydrogel Models”, Adv. Healthc. Mater. 10, 2002103 (2021).
M. A. Mohamed, A. Shahini, N. Rajabian, J. Caserto, A. M. A. El-Sokkary, M. A. Akl, S. T. Andreadis, C. Cheng, “Fast photocurable thiol-ene elastomers with tunable biodegradability, mechanical and surface properties enhance myoblast differentiation and contractile function”, Bioact. Mater. 6, 2120-2133 (2021).
H. T. dos Santos, K. Nam, C. T. Brown, S. M. Dean, S. Lewis, C. S. Pfeifer, P. Lei, M. J. Petris, S. T. Andreadis, O. J. Baker, “Trimers Conjugated to Fibrin Hydrogels Promote Salivary Gland Function”, J. Dent. Res. 100, 268-275 (2021).
N. Rajabian, A. Shahini, M. Asmani, K. Vydiam, D. Choudhury, T. Nguyen, I. Ikhapoh, R. G. Zhao, P. Lei, S. T. Andreadis, “Bioengineered Skeletal Muscle as a Model of Muscle Aging and Regeneration”, Tissue Eng. Part A 27, 74-86 (2021).
A. Jafari, N. Rajabian, G. Zhang, M. A. Mohamed, P. Lei, S. T. Andreadis, B. A. Pfeifer, C. Cheng, “PEGylated Amine-Functionalized Poly(epsilon-caprolactone) for the Delivery of Plasmid DNA”, Materials 13, 898 (2020).
R. J. Smith, B. Nasiri, J. Kann, D. Yergeau, J. E. Bard, D. D. Swartz, S. T. Andreadis, “Endothelialization of arterial vascular grafts by circulating monocytes”, Nat. Commun. 11, 1622 (2020).
B. Nasiri, S. Row, R. J. Smith, D. D. Swartz, S. T. Andreadis, “Cell-Free Vascular Grafts That Grow with the Host”, Adv. Funct. Mater. 30, 2005769 (2020).
C. T. Brown, K. Nam, Y. Zhang, Y. Qiu, S. M. Dean, H. T. dos Santos, P. Lei, S. T. Andreadis, O. J. Baker, “Sex-dependent Regeneration Patterns in Mouse Submandibular Glands”, J. Histochem. Cytochem. 68, 305-318 (2020).
R. Z. Samuel, P. Lei, K. Nam, O. J. Baker, S. T. Andreadis, “Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels”, Acta Biomater. 105, 121-130 (2020).
P. Mehrotra, G. Tseropoulos, M. E. Bronner, S. T. Andreadis, “Adult tissue-derived neural crest-like stem cells: Sources, regulatory networks, and translational potential: Concise review”, Stem Cells Transl. Med. 9, 328-341 (2020).
Y. Y. Liu, P. Lei, S. Row, S. T. Andreadis, “Cadherin-11 binds to PDGFR beta and enhances cell proliferation and tissue regeneration via the PDGFR-AKT signaling axis”, Faseb J. 34, 3792-3804 (2020).
M. Beitelshees, A. Hill, Y. Li, M. F. Chen, M. K. Ahmadi, R. J. Smith, S. T. Andreadis, P. Rostami, C. H. Jones, B. A. Pfeifer, “Antigen delivery format variation and formulation stability through use of a hybrid vector”, Vaccine: X 1, 100012 (2019).
M. A. Mohamed, A. Fallahi, A. M. A. El-Sokkary, S. Salehi, M. A. Akl, A. Jafari, A. Tamayol, H. Fenniri, A. Khademhosseini, S. T. Andreadis, C. Cheng, “Stimuli-responsive hydrogels for manipulation of cell microenvironment: From chemistry to biofabrication technology”, Prog. Polym. Sci. 98, UNSP 101147 (2019).
N. Rong, P. Mistriotis, X. Y. Wang, G. Tseropoulos, N. Rajabian, Y. L. Zhang, J. M. Wang, S. Liu, S. T. Andreadis, “Restoring extracellular matrix synthesis in senescent stem cells”, Faseb J. 33, 10954-10965 (2019).
S. M. Boroujeni, A. Koontz, G. Tseropoulos, L. Kerosuo, P. Mehrotra, V. K. Bajpai, S. R. Selvam, P. Lei, M. E. Bronner, S. T. Andreadis, “Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo”, Sci. Rep. 9, 9750 (2019).
K. Nam, S. M. Dean, C. T. Brown, R. J. Smith, P. Lei, S. T. Andreadis, O. J. Baker, “Synergistic effects of laminin-1 peptides, VEGF and FGF9 on salivary gland regeneration”, Acta Biomater. 91, 186-194 (2019).
R. J. Smith, T. Yi, B. Nasiri, C. K. Breuer, S. T. Andreadis, “Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response”, Faseb J. 33, 5089-5100 (2019).
A. Shahini, K. Vydiam, D. Choudhury, N. Rajabian, T. Nguyen, P. Lei, S. T. Andreadis, “Efficient and high yield isolation of myoblasts from skeletal muscle”, Stem Cell Res. 30, 122-129 (2018).
G. Tseropoulos, S. M. Boroujeni, V. K. Bajpai, P. Lei, S. T. Andreadis, “Derivation of neural crest stem cells from human epidermal keratinocytes requires FGF-2, IGF-1, and inhibition of TGF-beta 1”, Bioeng. Transl. Med. 3, 256-264 (2018).
A. Shahini, D. Choudhury, M. Asmani, R. G. Zhao, P. Lei, S. T. Andreadis, “NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings”, Stem Cell Res. 26, 55-66 (2018).
K. Nam, C. S. Wang, C. L. M. Maruyama, P. Lei, S. T. Andreadis, O. J. Baker, “L1 Peptide-Conjugated Fibrin Hydrogels Promote Salivary Gland Regeneration”, J. Dent. Res. 96, 798-806 (2017).
P. Mistriotis, S. T. Andreadis, “Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation”, Ageing Res. Rev. 37, 94-116 (2017).
K. Nam, C. L. Maruyama, C. S. Wang, B. G. Trump, P. Lei, S. T. Andreadis, O. J. Baker, “Laminin-111-derived peptide conjugated fibrin hydrogel restores salivary gland function”, PLoS One 12, e0187069 (2017).
D. Verma, V. K. Bajpai, N. N. Ye, M. M. Maneshi, D. Jetta, S. T. Andreadis, F. Sachs, S. Z. Hua, “Flow induced adherens junction remodeling driven by cytoskeletal forces”, Exp. Cell Res. 359, 327-336 (2017).
A. Shahini, P. Mistriotis, M. Asmani, R. G. Zhao, S. T. Andreadis, “NANOG Restores Contractility of Mesenchymal Stem Cell-Based Senescent Microtissues”, Tissue Eng. Part A 23, 535-+ (2017).
V. K. Bajpai, L. Kerosuo, G. Tseropoulos, K. A. Cummings, X. Y. Wang, P. Lei, B. Liu, S. Liu, G. K. Popescu, M. E. Bronner, S. T. Andreadis, “Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates”, Stem Cells 35, 1402-1415 (2017). PDF
S. Row, A. Santandreu, D. D. Swartz, S. T. Andreadis, “Cell-free vascular grafts: Recent developments and clinical potential”, Technology 5, 13-20 (2017).
P. Mistriotis, V. K. Bajpai, X. Y. Wang, N. Rong, A. Shahini, M. Asmani, M. S. Liang, J. M. Wang, P. Lei, S. Liu, R. G. Zhao, S. T. Andreadis, “NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression”, Stem Cells 35, 207-221 (2017).
K. Nam, J. P. Jones, P. Lei, S. T. Andreadis, O. J. Baker, “Laminin-111 Peptides Conjugated to Fibrin Hydrogels Promote Formation of Lumen Containing Parotid Gland Cell Clusters”, Biomacromolecules 17, 2293-2301 (2016).
H. Lee, D. Koh, L. Xu, S. Row, S. T. Andreadis, K. W. Oh, “A Simple Method for Fabrication of Microstructures Using a PDMS Stamp”, Micromachines 7, 173 (2016).
X. Yuan, R. J. Smith, H. Y. Guan, C. N. Ionita, P. Khobragade, R. Dziak, Z. P. Liu, M. H. Pang, C. D. Wang, G. Q. Guan, S. Andreadis, S. Y. Yang, “Hybrid Biomaterial with Conjugated Growth Factors and Mesenchymal Stem Cells for Ectopic Bone Formation”, Tissue Eng. Part A 22, 928-939 (2016).
Y. Li, M. Beitelshees, L. Fang, A. Hill, M. K. Ahmadi, M. Chen, B. A. Davidson, P. Knight, R. J. Smith, S. T. Andreadis, A. P. Hakansson, C. H. Jones, B. A. Pfeifer, “In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector”, Sci. Adv. 2, e1600264 (2016).
S. Row, Y. Y. Liu, S. Alimperti, S. K. Agarwal, S. T. Andreadis, “Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics”, J. Cell Sci. 129, 2950-2961 (2016).
M. T. Koobatian, S. Row, R. J. Smith, C. Koenigsknecht, S. T. Andreadis, D. D. Swartz, “Successful endothelialization and remodeling of a cell-free small-diameter arterial graft in a large animal model”, Biomaterials 76, 344-358 (2016).
N. Likhite, C. A. Jackson, M. S. Liang, M. C. Krzyzanowski, P. Lei, J. F. Wood, B. Birkaya, K. L. Michaels, S. T. Andreadis, S. D. Clark, M. C. Yu, D. M. Ferkey, “The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling”, Sci. Signal. 8, ra115 (2015).
J. Moharil, P. Lei, J. Tian, D. P. Gaile, S. T. Andreadis, “Lentivirus Live Cell Array for Quantitative Assessment of Gene and Pathway Activation during Myogenic Differentiation of Mesenchymal Stem Cells”, PLoS One 10, e0141365 (2015).
M. T. Koobatian, C. Koenigsknecht, S. Row, S. Andreadis, D. Swartz, “Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring”, J. Vis. Exp. (98), e52354 (2015).
S. Alimperti, S. T. Andreadis, “CDH2 and CDH11 act as regulators of stem cell fate decisions”, Stem Cell Res. 14, 270-282 (2015).
S. Son, M. S. Liang, P. Lei, X. Z. Xue, E. P. Furlani, S. T. Andreadis, “Magnetofection Mediated Transient NANOG Overexpression Enhances Proliferation and Myogenic Differentiation of Human Hair Follicle Derived Mesenchymal Stem Cells”, Bioconjugate Chem. 26, 1314-1327 (2015).
M. T. Koobatian, M. S. Liang, D. D. Swartz, S. T. Andreadis, “Differential Effects of Culture Senescence and Mechanical Stimulation on the Proliferation and Leiomyogenic Differentiation of MSC from Different Sources: Implications for Engineering Vascular Grafts”, Tissue Eng. Part A 21, 1364-1375 (2015).
S. Row, H. F. Peng, E. M. Schlaich, C. Koenigsknecht, S. T. Andreadis, D. D. Swartz, “Arterial grafts exhibiting unprecedented cellular infiltration and remodeling in vivo: The role of cells in the vascular wall”, Biomaterials 50, 115-126 (2015).
R. J. Smith, M. T. Koobatian, A. Shahini, D. D. Swartz, S. T. Andreadis, “Capture of endothelial cells under flow using immobilized vascular endothelial growth factor”, Biomaterials 51, 303-312 (2015).
R. M. Padmashali, P. Mistriotis, M. S. Liang, S. T. Andreadis, “Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation”, Mol. Ther. 22, 1971-1982 (2014).
Y. Lu, Y. H. Loh, H. Li, M. Cesana, S. B. Ficarro, J. R. Parikh, N. Salomonis, C. X. D. Toh, S. T. Andreadis, C. J. Luckey, J. J. Collins, G. Q. Daley, J. A. Marto, “Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells”, Cell Stem Cell 15, 92-101 (2014).
S. Alimperti, P. Lei, Y. Wen, J. Tian, A. M. Campbell, S. T. Andreadis, “Serum-Free Spheroid Suspension Culture Maintains Mesenchymal Stem Cell Proliferation and Differentiation Potential”, Biotechnol. Prog. 30, 974-983 (2014).
S. Alimperti, H. You, T. George, S. K. Agarwal, S. T. Andreadis, “Cadherin-11 regulates both mesenchymal stem cell differentiation into smooth muscle cells and the development of contractile function in vivo”, J. Cell Sci. 127, 2627-2638 (2014).
M. Ghionzoli, A. Repele, L. Sartiani, G. Costanzi, A. Parenti, V. Spinelli, A. L. David, M. Garriboli, G. Totonelli, J. Tian, S. T. Andreadis, E. Cerbai, A. Mugelli, A. Messineo, A. Pierro, S. Eaton, P. De coppi, “Human amniotic fluid stem cell differentiation along smooth muscle lineage”, Faseb J. 27, 4853-4865 (2013).
R. Padmashali, H. You, N. Karnik, P. Lei, S. T. Andreadis, “Adherens Junction Formation Inhibits Lentivirus Entry and Gene Transfer”, PLoS One 8, e79265 (2013).
C. K. Chen, C. H. Jones, P. Mistriotis, Y. Yu, X. N. Ma, A. Ravikrishnan, M. Jiang, S. T. Andreadis, B. A. Pfeifer, C. Cheng, “Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery”, Biomaterials 34, 9688-9699 (2013).
D. D. Swartz, S. T. Andreadis, “Animal models for vascular tissue-engineering”, Curr. Opin. Biotechnol. 24, 916-925 (2013).
A. D. Mccall, J. W. Nelson, N. J. Leigh, M. E. Duffey, P. Lei, S. T. Andreadis, O. J. Baker, “Growth Factors Polymerized Within Fibrin Hydrogel Promote Amylase Production in Parotid Cells”, Tissue Eng. Part A 19, 2215-2225 (2013).
M. S. Liang, M. Koobatian, P. Lei, D. D. Swartz, S. T. Andreadis, “Differential and synergistic effects of mechanical stimulation and growth factor presentation on vascular wall function”, Biomaterials 34, 7281-7291 (2013).
H. You, R. M. Padmashali, A. Ranganathan, P. Lei, N. Girnius, R. J. Davis, S. T. Andreadis, “JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues”, J. Cell Sci. 126, 2718-2729 (2013).
P. Mistriotis, S. T. Andreadis, “Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine”, Tissue Eng. Part B-Rev. 19, 265-278 (2013).
X. N. He, R. Dziak, X. Yuan, K. Y. Mao, R. Genco, M. Swihart, D. Sarkar, C. Y. Li, C. D. Wang, L. Lu, S. Andreadis, S. Y. Yang, “BMP2 Genetically Engineered MSCs and EPCs Promote Vascularized Bone Regeneration in Rat Critical-Sized Calvarial Bone Defects”, PLoS One 8, e60473 (2013).
S. T. Andreadis, “Give your heart a chance: match the muscle to the vessel”, Cardiovasc. Res. 98, 1-2 (2013).
S. Alimperti, P. Lei, J. Tian, S. T. Andreadis, “A novel lentivirus for quantitative assessment of gene knockdown in stem cell differentiation”, Gene Ther. 19, 1123-1132 (2012).
J. H. Han, P. Mistriotis, P. Lei, D. Wang, S. Liu, S. T. Andreadis, “Nanog Reverses the Effects of Organismal Aging on Mesenchymal Stem Cell Proliferation and Myogenic Differentiation Potential”, Stem Cells 30, 2746-2759 (2012).
V. K. Bajpai, P. Mistriotis, Y. H. Loh, G. Q. Daley, S. T. Andreadis, “Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates”, Cardiovasc. Res. 96, 391-400 (2012).
V. K. Bajpai, S. T. Andreadis, “Stem Cell Sources for Vascular Tissue Engineering and Regeneration”, Tissue Eng. Part B-Rev. 18, 405-425 (2012).
J. Wang, P. Lei, S. T. Andreadis, T. J. Mountziaris, “DETECTION OF DNA HYBRIDIZATION VIA FLUORESCENCE INTENSITY VARIATIONS OF ZnSe-DNA QUANTUM DOT BIOSENSORS”, Anal. Lett. 45, 227-241 (2012).
V. K. Bajpai, P. Mistriotis, S. T. Andreadis, “Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells”, Stem Cell Res. 8, 74-84 (2012).
H. F. Peng, E. M. Schlaich, S. Row, S. T. Andreadis, D. D. Swartz, “A Novel Ovine ex vivo Arteriovenous Shunt Model to Test Vascular Implantability”, Cells Tissues Organs 195, 108-121 (2012).
M. S. Liang, S. T. Andreadis, “Engineering fibrin-binding TGF-beta 1 for sustained signaling and contractile function of MSC based vascular constructs”, Biomaterials 32, 8684-8693 (2011).
M. H. Lee, R. Padmashali, P. Koria, S. T. Andreadis, “JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion”, Faseb J. 25, 613-623 (2011).
L. M. Lugo, P. Lei, S. T. Andreadis, “Vascularization of the Dermal Support Enhances Wound Re-Epithelialization by In Situ Delivery of Epidermal Keratinocytes”, Tissue Eng. Part A 17, 665-675 (2011).
M. H. Lee, R. Padmashali, S. T. Andreadis, “JNK1 Is Required for Lentivirus Entry and Gene Transfer”, J. Virol. 85, 2657-2665 (2011).
R. M. Padmashali, S. T. Andreadis, “Engineering fibrinogen-binding VSV-G envelope for spatially- and cell-controlled lentivirus delivery through fibrin hydrogels”, Biomaterials 32, 3330-3339 (2011).
H. F. Peng, J. Y. Liu, S. T. Andreadis, D. D. Swartz, “Hair Follicle-Derived Smooth Muscle Cells and Small Intestinal Submucosa for Engineering Mechanically Robust and Vasoreactive Vascular Media”, Tissue Eng. Part A 17, 981-990 (2011).
J. Tian, S. Alimperti, P. Lei, S. T. Andreadis, “Lentiviral microarrays for real-time monitoring of gene expression dynamics”, Lab Chip 10, 1967-1975 (2010).
S. D. Raut, P. Lei, R. M. Padmashali, S. T. Andreadis, “Fibrin-mediated lentivirus gene transfer: Implications for lentivirus microarrays”, J. Control. Release 144, 213-220 (2010).
J. H. Han, J. Y. Liu, D. D. Swartz, S. T. Andreadis, “Molecular and functional effects of organismal ageing on smooth muscle cells derived from bone marrow mesenchymal stem cells”, Cardiovasc. Res. 87, 147-155 (2010).
J. Y. Liu, H. F. Peng, S. Gopinath, J. Tian, S. T. Andreadis, “Derivation of Functional Smooth Muscle Cells from Multipotent Human Hair Follicle Mesenchymal Stem Cells”, Tissue Eng. Part A 16, 2553-2564 (2010).
R. Singh, J. Nitsche, S. T. Andreadis, “An Integrated Reaction-Transport Model for DNA Surface Hybridization: Implications for DNA Microarrays”, Ann. Biomed. Eng. 37, 255-269 (2009).
J. Tian, S. T. Andreadis, “Independent and high-level dual-gene expression in adult stem-progenitor cells from a single lentiviral vector”, Gene Ther. 16, 874-884 (2009).
P. Lei, R. M. Padmashali, S. T. Andreadis, “Cell-controlled and spatially arrayed gene delivery from fibrin hydrogels”, Biomaterials 30, 3790-3799 (2009).
R. Singh, P. Lei, S. T. Andreadis, “PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering”, Exp. Cell Res. 315, 2899-2913 (2009).
M. H. Lee, P. Koria, J. Qu, S. T. Andreadis, “JNK phosphorylates beta-catenin and regulates adherens junctions”, Faseb J. 23, 3874-3883 (2009).
L. Yao, J. Y. Liu, S. T. Andreadis, “Composite fibrin scaffolds increase mechanical strength and preserve contractility of tissue engineered blood vessels”, Pharm. Res. 25, 1212-1221 (2008).
J. Tian, P. Lei, S. G. Laychock, S. T. Andreadis, “Regulated insulin delivery from human epidermal cells reverses hyperglycemia”, Mol. Ther. 16, 1146-1153 (2008).
J. Y. Liu, H. F. Peng, S. T. Andreadis, “Contractile smooth muscle cells derived from hair-follicle stem cells”, Cardiovasc. Res. 79, 24-33 (2008).
J. Y. Liu, D. D. Swartz, H. F. Peng, S. F. Gugino, J. A. Russell, S. T. Andreadis, “Functional tissue-engineered blood vessels from bone marrow progenitor cells”, Cardiovasc. Res. 75, 618-628 (2007).
S. T. Andreadis, “Gene-modified tissue-engineered skin: The next generation of skin substitutes”, Adv. Biochem. Eng. Biotechnol. 103, 241-274 (2007).
R. Singh, S. T. Andreadis, “EGF receptor activation decreases retroviral gene transfer through protein kinase C-delta”, Mol. Ther. 15, 369-377 (2007).
K. G. Cornwell, P. Lei, S. T. Andreadis, G. D. Pins, “Crosslinking of discrete self-assembled collagen threads: Effects on mechanical strength and cell-matrix interactions”, J. Biomed. Mater. Res. Part A 80A, 362-371 (2007).
P. Lei, A. Ogunade, K. L. Kirkwood, S. G. Laychock, S. T. Andreadis, “Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: Implications for treatment of diabetes”, Tissue Eng. 13, 2119-2131 (2007).
P. Koria, S. T. Andreadis, “KGF promotes integrin alpha(5) expression through CCAAT/enhancer-binding protein-beta”, Am. J. Physiol.-Cell Physiol. 293, C1020-C1031 (2007).
S. T. Andreadis, D. J. Geer, “Biomimetic approaches to protein and gene delivery for tissue regeneration”, Trends Biotechnol. 24, 331-337 (2006).
P. Koria, S. T. Andreadis, “Epidermal morphogenesis: The transcriptional program of human keratinocytes during stratification”, J. Invest. Dermatol. 126, 1834-1841 (2006).
S. T. Andreadis, “Experimental models and high-throughput diagnostics for tissue regeneration”, Expert Opin. Biol. Ther. 6, 1071-1086 (2006).
B. G. Bajaj, P. Lei, S. T. Andreadis, “Efficient gene transfer to human epidermal keratinocytes on fibronectin: In vitro evidence for transduction of epidermal stem cells”, Mol. Ther. 11, 969-979 (2005).
D. D. Swartz, J. A. Russell, S. T. Andreadis, “Engineering of fibrin-based functional and implantable small-diameter blood vessels”, Am. J. Physiol.-Heart Circul. Physiol. 288, H1451-H1460 (2005).
P. Lei, S. T. Andreadis, “Stoichiometric limitations in assembly of active recombinant retrovirus”, Biotechnol. Bioeng. 90, 781-792 (2005).
L. Yao, D. D. Swartz, S. F. Gugino, J. A. Russell, S. T. Andreadis, “Fibrin-based tissue-engineered blood vessels: Differential effects of biomaterial and culture parameters on mechanical strength and vascular reactivity”, Tissue Eng. 11, 991-1003 (2005).
D. J. Geer, D. D. Swartz, S. T. Andreadis, “Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo”, Am. J. Pathol. 167, 1575-1586 (2005).
S. T. Andreadis, “Gene transfer to epidermal stem cells: implications for tissue engineering”, Expert Opin. Biol. Ther. 4, 783-800 (2004).
D. J. Geer, D. D. Swartz, S. T. Andreadis, “In vivo model of wound healing based on transplanted tissue-engineered skin”, Tissue Eng. 10, 1006-1017 (2004).
P. Koria, D. Brazeau, K. Kirkwood, P. Hayden, M. Klausner, S. T. Andreadis, “Gene expression profile of tissue engineered skin subjected to acute barrier disruption”, J. Invest. Dermatol. 121, 368-382 (2003).
D. J. Geer, S. T. Andreadis, “A novel role of fibrin in epidermal healing: Plasminogen-mediated migration and selective detachment of differentiated keratinocytes”, J. Invest. Dermatol. 121, 1210-1216 (2003).
K. Kirkwood, T. Martin, S. T. Andreadis, Y. J. Kim, “Chemically modified tetracyclines selectively inhibit IL-6 expression in osteoblasts by decreasing mRNA stability”, Biochem. Pharmacol. 66, 1809-1819 (2003).
P. Lei, B. Bajaj, S. T. Andreadis, “Retrovirus-associated heparan sulfate mediates immobilization and gene transfer on recombinant fibronectin”, J. Virol. 76, 8722-8728 (2002).
B. Bajaj, S. Behshad, S. T. Andreadis, “Retroviral gene transfer to human epidermal keratinocytes correlates with integrin expression and is significantly enhanced on fibronectin”, Hum. Gene Ther. 13, 1821-1831 (2002).
D. J. Geer, D. D. Swartz, S. T. Andreadis, “Fibrin promotes migration in a three-dimensional in vitro model of wound regeneration”, Tissue Eng. 8, 787-798 (2002).
P. Lei, B. Bajaj, S. T. Andreadis, “Retrovirus-associated heparan sulfate mediates immobilization and gene transfer on recombinant fibronectin (vol 76, pg 8722, 2002)”, J. Virol. 76, 11176-11176 (2002).
S. T. Andreadis, K. E. Hamoen, M. L. Yarmush, J. R. Morgan, “Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system”, Faseb J. 15, 898-906 (2001).
B. Bajaj, P. Lei, S. T. Andreadis, “High efficiencies of gene transfer with immobilized recombinant retrovirus: Kinetics and optimization”, Biotechnol. Prog. 17, 587-596 (2001).
S. Andreadis, T. Lavery, H. E. Davis, J. M. Le Doux, M. L. Yarmush, J. R. Morgan, “Toward a more accurate quantitation of the activity of recombinant retroviruses: Alternatives to titer and multiplicity of infection”, J. Virol. 74, 1258-1266 (2000).
S. T. Andreadis, C. M. Roth, J. M. Le Doux, J. R. Morgan, M. L. Yarmush, “Large-scale processing of recombinant retroviruses for gene therapy”, Biotechnol. Prog. 15, 1-11 (1999).
S. Andreadis, A. O. Fuller, B. O. Palsson, “Cell cycle dependence of retroviral transduction: An issue of overlapping time scales”, Biotechnol. Bioeng. 58, 272-281 (1998).
B. Palsson, S. Andreadis, "The physico-chemical factors that govern retrovirus-mediated gene transfer", Exp. Hematol. 25, 94-102 (1997). abstract
S. Andreadis, B. O. Palsson, “Coupled effects of polybrene and calf serum on the efficiency of retroviral transduction and the stability of retroviral vectors”, Hum. Gene Ther. 8, 285-291 (1997).
S. T. Andreadis, D. Brott, A. O. Fuller, B. O. Palsson, "Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours", J. Virol. 71, 7541-7548 (1997). abstract
S. T. Andreadis, B. O. Palsson, “Kinetics of retrovirus mediated gene transfer: The importance of intracellular half-life of retroviruses”, J. Theor. Biol. 182, 1-20 (1996).

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Stelios Andreadis

PhD

Stelios Andreadis

PhD

Stelios Andreadis

PhD

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Department of Biomedical Engineering

ACS Appl. Bio Mater.	Acta Biomater.	Adv. Biochem. Eng. Biotechnol.
Adv. Funct. Mater.	Adv. Healthc. Mater.	Advanced Science
Ageing Res. Rev.	Aging Cell	Am. J. Pathol.
Am. J. Physiol.-Cell Physiol.	Am. J. Physiol.-Heart Circul. Physiol.	Anal. Lett.
Ann. Biomed. Eng.	APL Bioeng.	Bioact. Mater.
Biochem. Pharmacol.	Bioconjugate Chem.	Bioeng. Transl. Med.
Biomacromolecules	Biomaterials	Biotechnol. Bioeng.
Biotechnol. Prog.	Cardiovasc. Res.	Cell Reports
Cell Stem Cell	Cells Tissues Organs	Chem. Mat.
Curr. Opin. Biotechnol.	Exp. Cell Res.	Exp. Hematol.
Expert Opin. Biol. Ther.	Faseb J.	Front. Bioeng. Biotechnol.
Gene Ther.	Hum. Gene Ther.	Int. J. Mol. Sci.
J. Biomed. Mater. Res. Part A	J. Cell Sci.	J. Control. Release
J. Dent. Res.	J. Histochem. Cytochem.	J. Invest. Dermatol.
J. Membr. Sci.	J. Theor. Biol.	J. Virol.
J. Vis. Exp.	Lab Chip	Materials
Microb. Cell. Fact.	Micromachines	Mol. Oncol.
Mol. Ther.	Nat. Commun.	Nutrition
Pharm. Res.	PLoS One	Prog. Polym. Sci.
Sci. Adv.	Sci. Rep.	Sci. Signal.
Stem Cell Res.	Stem Cells	Stem Cells Transl. Med.
Technology	Tissue Eng.	Tissue Eng. Part A
Tissue Eng. Part B-Rev.	Trends Biotechnol.	Vaccine: X