Published May 21, 2020
An article in Genetic Engineering & Biotechnology News reports that a research team that includes UB’s Jonathan Lovell, associate professor of biomedical engineering, has identified an approach that improves drug delivery to tumor sites.
“Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery,” write the investigators.
Entitled “Nanobowl-Supported Liposomes Improve Drug Loading and Delivery”, the paper was published in the American Chemical Society’s Nano Letters.
