Diabetic kidney disease (DKD) is a serious complication of both type 1 and type 2 diabetes and is the leading cause of kidney failure. Yet, it is still not clear how the many underlying chemical, physical, and biological processes interact to damage the kidneys during diabetes. It is challenging to monitor the damage to the kidneys inside a patient. The regions of the kidney that are damaged are very small and are deep within the body. It takes a long time for irreversible damage to accumulate to the point where non-invasive urine samples contain detectable quantities of proteins that leaked through the kidneys.
This project involves connecting several processes that have been shown individually to contribute to injury in kidneys due to diabetes into a sophisticated computer simulation. This computational tool will aid in understanding how the processes interact and how diabetic kidney damage begins and changes over time. In the long-term, results from this project will help to predict the impacts of many competing factors on kidney health during diabetes management. The computer simulation produced in the project can also be used to test and optimize treatments to slow the progression of DKD. The project also will involve a set of educational activities related to the scientific work. Several undergraduate and graduate students including women and underrepresented minorities are working with Dr. Ford Versypt to conduct the research and educational activities.
Educational modules related to the research have been delivered to a variety of groups including K-12 students, college students, and grandparents. Physical models of kidney tissues have been 3D-printed and shared with students and educators. The activities will expose many students and members of the public to biomedical engineering and computational science through engaging scientific demonstrations and interactive experiences.