Leonid Khinkis

PhD

Leonid Khinkis.

Leonid Khinkis

PhD

Leonid Khinkis

PhD

Professor of Teaching
Institute for Artificial Intelligence and Data Science
School of Engineering and Applied Sciences

Research Topics

Nonlinear regression with applications to pharmacokinetics/pharmacodynamics; design of experiments; deep learning.

Biography Publications Teaching

Latest Publications

  • Khinkis, L. (2019) On a global measure of nonlinearity and its application in parameter estimation in nonlinear regression. Mathematics for Applications, 8, pp. 101-114. DOI: 10.13164/ma.2019.07.
  • Khinkis, L., Crotzer, M. (2019) Application of new measures of nonlinearity to parameter estimation and simulations in individual pharmacokinetic analyses. Journal of Pharmacokinetics and Pharmacodynamics, 46(1), pp.43-52. DOI: 10.1007/s10928-018-09616-1.
  • Khinkis, L., Crotzer, M., and Oprisan, A. (2018) Sizing up the regions of unique minima in the least squares nonlinear regression. Mathematics for Applications, 7, pp. 41-52.
  • Khinkis, L., Krzyzanski, W., Jusko, W.J., and Greco, W.R. (2009) D-optimal designs for parameter estimation for indirect pharmacodynamic response models. Journal of Pharmacokinetics and Pharmacodynamics, 36, pp. 523-539.
  • White, D.B., Faessel, H.M., Slocum H.K., Khinkis, L.A., and Greco, W.R. (2004) Nonlinear response surface and mixture experiment methodologies applied to the study of synergism. Biometrical Journal, (1), pp. 56-71.
  • Khinkis, L.A., Levasseur, L., Faessel, H., and Greco, W.R. (2003) Optimal design for estimating parameters of the 4-parameter Hill model. Nonlinearity in Biology, Toxicology, and Medicine (1), pp. 363-377.
  • Bucki, C., Khinkis, L.A., Malmberg, A., Parsons, J., and Greco, W.R. (2001) Monte Carlo investigation of rival experimental designs for the Hill model. Monte Carlo Simulation. A. A. Balkema Publishers, the Netherlands, pp. 247-253.
  • Faessel, H., Slokum, H.K., Rustum, Y.M., Khinkis, L.A., Kaya, U., and Greco, W.R. (1997) Patterns of concentration-effect curves and isoboles for two-drug mixtures. Pharmaceutical Research, (11), v.14, pp. S-559-S-560.
  • Greco, W.R., Sutor, D.C., Parsons, J.C., Khinkis, L.A. et al. (1994) Monte-Carlo comparison of rival experimental designs for two-agent combined-action studies. Canadian Journal of Infectious Diseases (5) (suppl.), pp. 51A-59A.
  • Khinkis, L.A. (1987). Spectral synthesis problem in functional spaces on semi-simple rank 1 Lie Groups. Published by Voronezh State University, Voronezh, Russia, pp. 1-13.
  • Khinkis, L.A. (1985). Invariant relative to the translation spaces on a semi-simple Lie Group. Proceedings of the Azerbaijan Academy of Sciences, 10, vol. 41, p. 10-11.