Johannes M. Nitsche
PhD
SUNY Distinguished Teaching Professor
Research Topics
Transport phenomena; bioactive surfaces; biological pores; transdermal transport
Publications
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- J. X. Wang, J. M. Nitsche, G. B. Kasting, G. Wittum, A. Nagel, “Transdermal and lateral effective diffusivities for drug transport in stratum corneum from a microscopic anisotropic diffusion model”, Eur. J. Pharm. Biopharm. 188, 271-286 (2023).
- J. M. Nitsche, G. B. Kasting, “A Framework for Incorporating Transient Solute-Keratin Binding Into Dermal Absorption Models”, J. Pharm. Sci. 111, 2093-2106 (2022).
- K. Tonnis, J. M. Nitsche, L. J. Xu, A. Haley, J. Jaworska, G. B. Kasting, “Impact of solvent dry down, vehicle pH and slowly reversible keratin binding on skin penetration of cosmetic relevant compounds: I. Liquids”, Int. J. Pharm. 624 (2022).
- O. Denysova, J. M. Nitsche, “Conclusions about osmotically inactive volume and osmotic fragility from a detailed erythrocyte model”, J. Theor. Biol. 539, 110982 (2022).
- L. C. Nitsche, G. B. Kasting, J. M. Nitsche, “Microscopic Models of Drug/Chemical Diffusion Through the Skin Barrier: Effects of Diffusional Anisotropy of the Intercellular Lipid”, J. Pharm. Sci. 108, 1692-1712 (2019).
- J. M. Nitsche, G. B. Kasting, “How Predictable Are Human Stratum Corneum Lipid/Water Partition Coefficients? Assessment and Useful Correlations for Dermal Absorption”, J. Pharm. Sci. 107, 727-738 (2018).
- J. M. Nitsche, G. B. Kasting, “A Universal Correlation Predicts Permeability Coefficients of Fluid- and Gel-Phase Phospholipid and Phospholipid-Cholesterol Bilayers for Arbitrary Solutes”, J. Pharm. Sci. 105, 1762-1771 (2016).
- J. M. Nitsche, G. B. Kasting, “A Microscopic Multiphase Diffusion Model of Viable Epidermis Permeability”, Biophys. J. 104, 2307-2320 (2013).
- J. M. Nitsche, G. B. Kasting, “Permeability of fluid-phase phospholipid bilayers: Assessment and useful correlations for permeability screening and other applications”, J. Pharm. Sci. 102, 2005-2032 (2013).
- J. M. Nitsche, G. B. Kasting, “A critique of Abraham and Acree's correlation for deca-1,9-diene/water partition coefficients”, New J. Chem. 37, 283-285 (2013).
- J. M. Nitsche, G. B. Kasting, “A correlation for 1,9-decadiene/water partition coefficients”, J. Pharm. Sci. 102, 136-144 (2013).
- R. Ibrahim, J. M. Nitsche, G. B. Kasting, “Dermal clearance model for epidermal bioavailability calculations”, J. Pharm. Sci. 101, 2094-2108 (2012).
- J. M. Nitsche, H. F. Frasch, “Dynamics of diffusion with reversible binding in microscopically heterogeneous membranes: General theory and applications to dermal penetration”, Chem. Eng. Sci. 66, 2019-2041 (2011).
- H. F. Frasch, A. M. Barbero, J. M. Hettick, J. M. Nitsche, “Tissue Binding Affects the Kinetics of Theophylline Diffusion Through the Stratum Corneum Barrier Layer of Skin”, J. Pharm. Sci. 100, 2989-2995 (2011).
- R. Singh, J. Nitsche, S. T. Andreadis, “An Integrated Reaction-Transport Model for DNA Surface Hybridization: Implications for DNA Microarrays”, Ann. Biomed. Eng. 37, 255-269 (2009).
- T. F. Wang, G. B. Kasting, J. M. Nitsche, “A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database”, J. Pharm. Sci. 96, 3024-3051 (2007).
- J. M. Nitsche, T. F. Wang, G. B. Kasting, “A two-phase analysis of solute partitioning into the stratum corneum”, J. Pharm. Sci. 95, 649-666 (2006).
- T. F. Wang, G. B. Kasting, J. M. Nitsche, “A multiphase microscopic diffusion model for stratum corneum permeability. I. Formulation, solution, and illustrative results for representative compounds”, J. Pharm. Sci. 95, 620-648 (2006).
- J. M. Nitsche, H. C. Chang, P. A. Weber, B. J. Nicholson, "A transient diffusion model yields unitary gap junctional permeabilities from images of cell-to-cell fluorescent dye transfer between Xenopus oocytes", Biophys. J. 86, 2058-2077 (2004). abstract
- P. A. Weber, H. C. Chang, K. E. Spaeth, J. M. Nitsche, B. J. Nicholson, “The permeability of gap junction channels to probes of different size is dependent on connexin composition and permeant-pore affinities”, Biophys. J. 87, 958-973 (2004).
- K. Kretsos, G. B. Kasting, J. M. Nitsche, “Distribution diffusion-clearance model for transient drug distribution within the skin”, J. Pharm. Sci. 93, 2820-2835 (2004).
- G. B. Kasting, N. D. Barai, T. F. Wang, J. M. Nitsche, “Mobility of water in human stratum corneum”, J. Pharm. Sci. 92, 2326-2340 (2003).
- V. Sikavitsas, J. M. Nitsche, T. J. Mountziaris, “Transport and kinetic processes underlying biomolecular interactions in the BIACORE optical biosensor”, Biotechnol. Prog. 18, 885-897 (2002).
- J. M. Nitsche, “Cellular microtransport processes: intercellular, intracellular, and aggregate behavior”, Annu. Rev. Biomed. Eng. 1, 463-503 (1999).
- D. S. Vaidya, J. M. Nitsche, S. L. Diamond, D. A. Kofke, “Reply to comments on "Convection-diffusion of solutes in media with piecewise constant transport properties"”, Chem. Eng. Sci. 54, 715-715 (1999). PDF
- T. M. Suchyna, J. M. Nitsche, M. Chilton, A. L. Harris, R. D. Veenstra, B. J. Nicholson, "Different tonic selectivities for connexins 26 and 32 produce rectifying gap junction channels", Biophys. J. 77, 2968-2987 (1999). abstract
- F. L. Cao, R. Eckert, C. Elfgang, J. M. Nitsche, S. A. Snyder, D. F. Hulser, K. Willecke, B. J. Nicholson, "A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes", J. Cell Sci. 111, 31-43 (1998). abstract
- P. Roy, J. M. Nitsche, “A study toward the scale-up of size-exclusion separations by stagewise countercurrent contact”, Sep. Sci. Technol. 32, 2237-2266 (1997).
- D. S. Vaidya, J. M. Nitsche, S. L. Diamond, D. A. Kofke, “Perturbation solution to the convection-diffusion equation with moving fronts”, AIChE J. 43, 631-644 (1997). PDF
- D. S. Vaidya, S. L. Diamond, J. M. Nitsche, D. A. Kofke, “Potential for use of liquid crystals as dynamically tunable electrophoretic media”, AIChE J. 43, 1366-1368 (1997). PDF
- J. M. Nitsche, G. K. Batchelor, “Break-up of a falling drop containing dispersed particles”, J. Fluid Mech. 340, 161-175 (1997).
- J. M. Nitsche, "On Brownian dynamics with hydrodynamic wall effects: A problem in diffusion near a fiber, and the meaning of the no-flux boundary condition", Chem. Eng. Commun. 150, 623-651 (1996). abstract
- D. S. Vaidya, J. M. Nitsche, S. L. Diamond, D. A. Kofke, “Convection-diffusion of solutes in dynamic media”, Adsorption 3, 41-54 (1996).
- J. M. Nitsche, “On the asymptotic structure of far-field electrostatic interactions between charged molecules and charged surfaces”, Ind. Eng. Chem. Res. 35, 3241-3247 (1996).
- J. M. Nitsche, P. Roy, “Shear-induced alignment of nonspherical Brownian particles near walls”, AIChE J. 42, 2729-2742 (1996).
- D. S. Vaidya, J. M. Nitsche, S. L. Diamond, D. A. Kofke, “Convection-diffusion of solutes in media with piecewise constant transport properties”, Chem. Eng. Sci. 51, 5299-5312 (1996). PDF
- Y. T. Wu, J. M. Nitsche, “ON DIFFUSION-LIMITED SITE-SPECIFIC ASSOCIATION PROCESSES FOR SPHERICAL AND NONSPHERICAL MOLECULES”, Chem. Eng. Sci. 50, 1467-1487 (1995).
- G. Balgi, D. E. Leckband, J. M. Nitsche, "TRANSPORT EFFECTS ON THE KINETICS OF PROTEIN-SURFACE BINDING", Biophys. J. 68, 2251-2260 (1995). abstract
- J. M. Nitsche, “PORE DIFFUSION OF NONSPHERICAL BROWNIAN PARTICLES”, Ind. Eng. Chem. Res. 34, 3606-3620 (1995).
- J. M. Nitsche, K. W. Limbach, “PARTITION-COEFFICIENTS FOR DISTRIBUTION OF RIGID NON-AXISYMMETRICAL SOLUTES BETWEEN BULK SOLUTION AND POROUS PHASES - TOWARD SHAPE-SELECTIVE SEPARATIONS WITH CONTROLLED-PORE MATERIALS”, Ind. Eng. Chem. Res. 33, 1391-1396 (1994).
- J. M. Nitsche, G. Balgi, “HINDERED BROWNIAN DIFFUSION OF SPHERICAL SOLUTES WITHIN CIRCULAR CYLINDRICAL PORES”, Ind. Eng. Chem. Res. 33, 2242-2247 (1994).
- G. K. Batchelor, J. M. Nitsche, “EXPULSION OF PARTICLES FROM A BUOYANT BLOB IN A FLUIDIZED-BED”, J. Fluid Mech. 278, 63-81 (1994).
- G. K. Batchelor, J. M. Nitsche, “INSTABILITY OF STRATIFIED FLUID IN A VERTICAL CYLINDER”, J. Fluid Mech. 252, 419-448 (1993).
- J. M. Nitsche, “NEW APPLICATIONS OF KAHL VLE ANALYSIS TO ENGINEERING PHASE-BEHAVIOR CALCULATIONS”, Fluid Phase Equilib. 78, 157-190 (1992).
- J. M. Nitsche, J. Wei, “WINDOW EFFECTS IN ZEOLITE DIFFUSION AND BROWNIAN-MOTION OVER POTENTIAL BARRIERS”, AIChE J. 37, 661-670 (1991).