Thomas Grant

PhD

Thomas Grant

PhD

Thomas Grant

PhD

Research Topics

Protein crystallography and X-ray diffraction studies

Contact Information

Hauptman-Woodward Institute

700 Ellicott Street

Office 209

Buffalo NY, 14260

Phone: (716) 898-8675

tgrant@hwi.buffalo.edu

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Publications

  • Kupitz, C., Olmos, J. L., Jr., Holl, M., Tremblay, L., Pande, K., Pandey, S., Oberthur, D., Hunter, M., Liang, M., Aquila, A., Tenboer, J., Calvey, G., Katz, A., Chen, Y., Wiedorn, M. O., Knoska, J., Meents, A., Majriani, V., Norwood, T., Poudyal, I., Grant, T., Miller, M. D., Xu, W., Tolstikova, A., Morgan, A., Metz, M., Martin-Garcia, J. M., Zook, J. D., Roy-Chowdhury, S., Coe, J., Nagaratnam, N., Meza, D., Fromme, R., Basu, S., Frank, M., White, T., Barty, A., Bajt, S., Yefanov, O., Chapman, H. N., Zatsepin, N., Nelson, G., Weierstall, U., Spence, J., Schwander, P., Pollack, L., Fromme, P., Ourmazd, A., Phillips, G. N., Jr. & Schmidt, M. (2017). Structural enzymology using X-ray free electron lasers. Struct Dyn 4, 044003.
  • Stagno, J. R., Liu, Y., Bhandari, Y. R., Conrad, C. E., Panja, S., Swain, M., Fan, L., Nelson, G., Li, C., Wendel, D. R., White, T. A., Coe, J. D., Wiedorn, M. O., Knoska, J., Oberthuer, D., Tuckey, R. A., Yu, P., Dyba, M., Tarasov, S. G., Weierstall, U., Grant, T. D., Schwieters, C. D., Zhang, J., Ferre-D'Amare, A. R., Fromme, P., Draper, D. E., Liang, M., Hunter, M. S., Boutet, S., Tan, K., Zuo, X., Ji, X., Barty, A., Zatsepin, N. A., Chapman, H. N., Spence, J. C., Woodson, S. A. & Wang, Y. X. (2017). Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature 541, 242-246.
  • Pande, K., Hutchison, C. D., Groenhof, G., Aquila, A., Robinson, J. S., Tenboer, J., Basu, S., Boutet, S., DePonte, D. P., Liang, M., White, T. A., Zatsepin, N. A., Yefanov, O., Morozov, D., Oberthuer, D., Gati, C., Subramanian, G., James, D., Zhao, Y., Koralek, J., Brayshaw, J., Kupitz, C., Conrad, C., Roy- Chowdhury, S., Coe, J. D., Metz, M., Xavier, P. L., Grant, T. D., Koglin, J. E., Ketawala, G., Fromme, R., Srajer, V., Henning, R., Spence, J. C., Ourmazd, A., Schwander, P., Weierstall, U., Frank, M., Fromme, P., Barty, A., Chapman, H. N., Moffat, K., van Thor, J. J. & Schmidt, M. (2016). Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein. Science 352, 725-729.
  • Bailey, D. C., Drake, E. J., Grant, T. D. & Gulick, A. M. (2016). Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae. Biochemistry 55, 3559-3570.
  • Abdallah, B. G., Zatsepin, N. A., Roy-Chowdhury, S., Coe, J., Conrad, C. E., Dorner, K., Sierra, R. G., Stevenson, H. P., Camacho-Alanis, F., Grant, T. D., Nelson, G., James, D., Calero, G., Wachter, R. M., Spence, J. C., Weierstall, U., Fromme, P. & Ros, A. (2015). Microfluidic sorting of protein nanocrystals by size for X-ray free-electron laser diffraction. Struct Dyn 2, 041719.
  • Lawrence, R. M., Conrad, C. E., Zatsepin, N. A., Grant, T. D., Liu, H., James, D., Nelson, G., Subramanian, G., Aquila, A., Hunter, M. S., Liang, M., Boutet, S., Coe, J., Spence, J. C., Weierstall, U., Liu, W., Fromme, P., Cherezov, V. & Hogue, B. G. (2015). Serial femtosecond X-ray diffraction of enveloped virus microcrystals. Struct Dyn 2, 041720.
  • Grant, T. D., Luft, J. R., Carter, L. G., Matsui, T., Weiss, T. M., Martel, A. & Snell, E. H. (2015). The accurate assessment of small-angle X-ray scattering data. Acta Crystallogr D Biol Crystallogr 71, 45-56.
  • Rossi, P., Shi, L., Liu, G., Barbieri, C. M., Lee, H. W., Grant, T. D., Luft, J. R., Xiao, R., Acton, T. B., Snell, E. H., Montelione, G. T., Baker, D., Lange, O. F. & Sgourakis, N. G. (2015). A hybrid NMR/SAXS- based approach for discriminating oligomeric protein interfaces using Rosetta. Proteins 83, 309-317.
  • Monteiro, D. C., Patel, V., Bartlett, C. P., Nozaki, S., Grant, T. D., Gowdy, J. A., Thompson, G. S., Kalverda, A. P., Snell, E. H., Niki, H., Pearson, A. R. & Webb, M. E. (2015). The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A. Chem Biol 22, 492-503.
  • Luft, J. R., Grant, T. D., Wolfley, J. R. & Snell, E. H. (2014). A new view on crystal harvesting. J Appl Crystallogr 47, 1158-1161.
  • Tenboer, J., Basu, S., Zatsepin, N., Pande, K., Milathianaki, D., Frank, M., Hunter, M., Boutet, S., Williams, G. J., Koglin, J. E., Oberthuer, D., Heymann, M., Kupitz, C., Conrad, C., Coe, J., Roy-Chowdhury, S., Weierstall, U., James, D., Wang, D., Grant, T., Barty, A., Yefanov, O., Scales, J., Gati, C., Seuring, C., Srajer, V., Henning, R., Schwander, P., Fromme, R., Ourmazd, A., Moffat, K., Van Thor, J. J., Spence, J. C., Fromme, P., Chapman, H. N. & Schmidt, M. (2014). Time-resolved serial crystallography captures high- resolution intermediates of photoactive yellow protein. Science 346, 1242-1246.
  • Bruno, A. E., Ruby, A. M., Luft, J. R., Grant, T. D., Seetharaman, J., Montelione, G. T., Hunt, J. F. & Snell, E. H. (2014). Comparing chemistry to outcome: the development of a chemical distance metric, coupled with clustering and hierarchal visualization applied to macromolecular crystallography. PLoS One 9, e100782.
  • Grant, T. D., Luft, J. R., Wolfley, J. R., Snell, M. E., Tsuruta, H., Corretore, S., Quartley, E., Phizicky, E. M., Grayhack, E. J. & Snell, E. H. (2013). The structure of yeast glutaminyl-tRNA synthetase and modeling of its interaction with tRNA. J Mol Biol 425, 2480-2493.
  • Stiegler, A. L., Grant, T. D., Luft, J. R., Calderwood, D. A., Snell, E. H. & Boggon, T. J. (2013). Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex. PLoS One 8, e55591.
  • Grant, T. D., Snell, E. H., Luft, J. R., Quartley, E., Corretore, S., Wolfley, J. R., Snell, M. E., Hadd, A., Perona, J. J., Phizicky, E. M. & Grayhack, E. J. (2012). Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase. Nucleic Acids Res 40, 3723-3731.