Alan Friedman

PhD

Alan Friedman

PhD

Alan Friedman

PhD

Research Topics

Analytical chemistry; organometallic chemistry; photochemistry

Contact Information

515 Natural Sciences Complex

Buffalo NY, 14260

Phone: (716) 645-2771

alanfrie@buffalo.edu

Loading...

Recent Publications

(Graduate Student *, Undergraduate ≠, Post-Doc §)

  • OldAcre, A.N.; Friedman, A.E.; Cook, T.R. “A Self-Assembled Cofacial Cobalt Porphyrin Prism for Oxygen Reduction Catalysis” J. Am. Chem. Soc. 2017 In Press
  • Gerloff, J.; Sundar, I.K.; Freter, R.; Ansah, K.O.; Sekera, E.R.; Friedman, A.E.; Robinson, R.; Pagano, T.; and Rahman, I. “Inflammatory response and cellular resistance by different e-cigarette flavoring chemicals identified by GC-MS in e-liquids and e-vapors on human lung epithelial cells, fibroblasts, and monocytes” Applied In Vitro Toxicology 2017 In Press
  • Kosswattaarachchi, M.A.; Friedman, A.E.; Cook, T.R. “Characterization of a BODIPY Dye as Active Species for Redox Flow Batteries” Chem Sus Chem 2016 In Press
  • Zhang, Y.; Cox, J.M.; Friedman, A.E.; Benedict, J.B.; Cook, T.R. “Phosphorescent Organoplatinum(II) D2A2 Metallacycles: Synthesis, Self-Assembly and Photophysical Properties” J Coord Chem, 2016 69(11) 1914-1923 DOI:10.1080/00958972.2016.1177824
  • McDougall, W.; Tun, B.; Cheung, M.; Polevoda, B.; Salter, J.; Friedman, A.E.; Smith, H.C. “RNA Binding to APOBEC3G Induces the Disassembly of Functional Deaminase Complexes by Displacing Single-Stranded DNA Substrates” Nucleic Acids Research 2015 doi: 10.1093/nar/gkv970, Epub September 30.
  • Kappil, M.A.; Li, Q.; Li, A.; Dassanayke, P.S.; Xia, Y.; Nanes, J.A.; Darrah3, T.H.; Friedman4, A.E.; Friedman4, M.; Landrigan1, P.; Stodgell4, C.J.; Aagaard5, K.; Schadt6, E.; Murray7, J.; Clark8, E.B.; Dole9, N.; Culhane10, J.; Swanson11, J.; Varner8, M.; Moye12, J.; Kasten13, C.; Miller4, R.K.; Chen1, J.; Lambertini, L. “In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development” Epigenetics, In Revision 2015.
  • Li, Q.; Kappil, M.; Li, A.; Dassanayke, P.S.; Darrah, T.; Friedman, A.E.; Friedman, M.; Lambertini, L.; Landrigan, P.; Stodgell, C.J.; Aagaard, K.; Schadt, E.; Murray, J.; Clark, E.B.; Dole, N.; Culhane, J.; Swanson, J.; Varner, M.; Moye, J.; Kasten, C.; Miller, R.K.; Chen, J. “Exploring the Associations between microRNA Expression Profiles and Environmental Pollutants in Human Placenta from the National Children's Study (NCS)” Epigenetics 2015 Sep 2;10(9):793-802. DOI: 10.1080/15592294.2015.1066960
  • Lapek, J.D.; Tombline, G.; Kellersberger, K.A.; Friedman, M.R.; Friedman, A.E. “Evidence of NM23 Involvement in Two-Component Regulation in Human Cancer” Naunyn Schmiedebergs Arch Pharmacol 2015, Volume 388, Issue 2, pp. 161-173.
  • Yao, H.; Sundar, I.K.; Ahmad, T.; Friedman, A.E.; Phipps R.P.; Sime P.J.; McBurney, M.W.; Guarente, L.; and Rahman, I. “SIRT1 protects against cigarette smoke-induced lung oxidative stress via FOXO3- dependent mechanism” Am J Physiol Lung Cell Mol Physiol 2014 Vol. no. DOI: 10.1152/ajplung.00323.2013
  • Sundar, I.K.; Nevid, M.Z.≠; Friedman, A.E. (Co-Senior Author); Rahman, I. (Co-Senior Author) “Cigarette smoke induces distinct histone modifications in lung cells: implications in pathogenesis of COPD” J Proteome Res 2014, 13 (2), pp. 982–996.
  • Lapek, J.D.; Tombline, G.; Friedman, M.R.; Friedman, A.E. Self-Cleavage of Trypsin at Lysine Residues with Reductive Methylations” 2016, Biochemistry, Submitted.
  • Lapek, J.D.*; Tombline, G.; Friedman, A.E. “Histone H4 is a Marker for Cancer Progression” 2015, J Pro Res, In revision.
  • Yao, H.; Ohlmeier, S.; Friedman, A.E.; McBurney, M.W.; Bergmann, U.; Kinnula, V. L.; Rahman, I. “SIRT1 regulates cigarette smoke-dependent processing of microtubular Dpysl2/Crmp2 and other molecules involved in carbonyl stress, inflammation, lipid metabolism, and bioenergetics” 2015, J Pro Res, Submitted.
  • Yao, H.; Hwang, H.; Sundar, I.K.; Friedman, A.E.; McBurney, M.W.; Guarente, L.; Gu, W.; Kinnula, V.L.; and Rahman, I. “SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD” Am J Physiol Lung Cell Mol Physiol 2013 Nov;305(9):L615-24.
  • Tombline, G.; Schwingel, J.M.; Lapek, J.D.*; Friedman, A.E.; Darrah, T.; Maguire, M.; Van Alst, N.E.; Filiatrault, M.J.; and Iglewski, B.H. “Pseudomonas aeruginosa PA1006/NbvF is a Persulfide-Modified Protein that is Critical for Molybdenum Homeostasis” PLoS One 2013;8(2): e55593.
  • Badding, M.A.; Lapek, J.D.*; Friedman, A.E.; Dean, D.A. “Proteomic and functional analyses of protein- DNA complexes during gene transfer” Mol Ther 2013 Apr;21(4):775-85. doi: 10.1038/mt.2012.231.
  • Sundar, I.K.; Chung, S.; Hwang, J.; Lapek, J. D.*; Bulger, M.; Friedman, A.E., Yao, H.; Davie, J.R.; Rahman, I., “Mitogen- and Stress-Activated Kinase 1 (MSK1) Regulates Cigarette Smoke-Induced Histone Modifications on NF-κB-dependent Genes.” 2012 PLoS One 7(2): e31378.
  • Deane, R.; Singh, I.; Sagare, A.P.; Bell, R.D.; Ross, N.T.; LaRue, B.; Love, R.; Perry, S.; Paquette, N.; Deane, R.J.; Meenakshisundaram, T.; Zarcone, T.; Fritz, G.; Friedman, A.E.; Miller, B.L.; Zlokovic, B.V., “A novel multi-modal RAGE inhibitor controls Aβ-mediated brain disorder in mice.” J Clin Invest 2012 Apr 2;122(4):1377-92.
  • Jaffré F.; Friedman, A.E.; Hu, Z.; Mackman, N.; Blaxall B.C., “Beta-adrenergic Receptor Stimulation Transactivates Protease- activated Receptor 1 via MMP-13 in Cardiac Cells” 2012 Circulation Jun 19;125(24):2993-3003.
  • Lapek, J.D.*; McGrath, J.L.; Ricke, W.A.; Friedman, A.E., “LC/LC-MS/MS of an Innovative Prostate Human Epithelial Cancer (PHEC) in vitro Model System” J Chromatogr B Analyt Technol Biomed Life Sci 2012 Apr 15; 893-894:34-42.
  • MacGilvray, M.E.; Lapek, J.D.*; Friedman, A.E.; Quivey, R.G., “Cardiolipin biosynthesis in Streptococcus mutans is regulated in response to external pH” 2012 Microbiology Aug;158(Pt 8):2133-43.
  • Lapek J.D. Jr,*; Tombline G.; and Friedman A.E. “Mass spectrometry detection of histidine phosphorylation on NM23-H1.” J Proteome Res 2011 Feb 4;10(2):751-5.
  • Mattiacio J., Walter S., Brewer M., Domm W., Friedman A.E., Dewhurst S. “Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env.” Vaccine 2011 Mar 21;29(14):2637-47.
  • McCloskey, R.; Menges, C.; Friedman, A.; Patel, D.; and McCance, D.J. Human Papillomavirus 16 E6/E7 Upregulation of Nucleophosmin Is Important for Proliferation and Inhibition of Differentiation” J Virol 2011 May;84(10):5131-9.
  • Caito, S.; Rajendrasozhan, S.; Cook, S.; Chung, S.; Yao, H.; Friedman, A.E.; Brookes, P.S. and Rahman I.  “SIRT1 is a Redox Sensitive Deacetylase which is Post-translationally Modified by Oxidants and Carbonyl Stress.” FASEB 2010 Sep;24(9):3145-59.