The prognosis is grim for patients who have metastasis, where cancer cells spread from a localized tumor to other regions in the body. Cancer cells and the surrounding extracellular matrix (ECM) interact to facilitate migration of cancer cells during early metastasis. Cancer cells secrete particular enzymes to cut and align collagen fibers of the ECM. These ECM remodeling activities transform the ECM from a random fiber matrix into an oriented "fibrous highway" that enhances cancer cell migration. The Ford Versypt lab addresses remodeling of the ECM during metastasis and the impacts on cellular migration through dynamic heterogeneous ECM biomaterials. Hybrid partial differential equation and agent-based modeling approaches are used to predict the interactions in tumor microenvironments.