Stelios Andreadis

PhD

Stelios Andreadis

PhD

Stelios Andreadis

PhD

Research Topics

Stem cells for vascular tissue engineering; signaling pathways in cell-cell adhesion and wound healing; lentiviral vectors and lentiviral microarrays for high-throughput gene expression analysis and gene discovery

Contact Information

908 Furnas Hall

Buffalo NY, 14260

Phone: (716) 645-1202

Fax: (716) 645-3822

sandread@buffalo.edu

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Publications

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  • A. Shahini, P. Mistriotis, M. Asmani, R. G. Zhao, S. T. Andreadis, “NANOG Restores Contractility of Mesenchymal Stem Cell-Based Senescent Microtissues”, Tissue Eng. Part A 23, 535-+ (2017). link
  • V. K. Bajpai, L. Kerosuo, G. Tseropoulos, K. A. Cummings, X. Y. Wang, P. Lei, B. Liu, S. Liu, G. K. Popescu, M. E. Bronner, S. T. Andreadis, “Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates”, Stem Cells 35, 1402-1415 (2017). link PDF
  • S. Row, A. Santandreu, D. D. Swartz, S. T. Andreadis, “Cell-free vascular grafts: Recent developments and clinical potential”, Technology 5, 13-20 (2017). link
  • P. Mistriotis, V. K. Bajpai, X. Y. Wang, N. Rong, A. Shahini, M. Asmani, M. S. Liang, J. M. Wang, P. Lei, S. Liu, R. G. Zhao, S. T. Andreadis, “NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression”, Stem Cells 35, 207-221 (2017). link
  • H. Lee, D. Koh, L. Xu, S. Row, S. T. Andreadis, K. W. Oh, “A Simple Method for Fabrication of Microstructures Using a PDMS Stamp”, Micromachines 7, 173 (2016). link
  • X. Yuan, R. J. Smith, H. Y. Guan, C. N. Ionita, P. Khobragade, R. Dziak, Z. P. Liu, M. H. Pang, C. D. Wang, G. Q. Guan, S. Andreadis, S. Y. Yang, “Hybrid Biomaterial with Conjugated Growth Factors and Mesenchymal Stem Cells for Ectopic Bone Formation”, Tissue Eng. Part A 22, 928-939 (2016). link
  • Y. Li, M. Beitelshees, L. Fang, A. Hill, M. K. Ahmadi, M. Chen, B. A. Davidson, P. Knight, R. J. Smith, S. T. Andreadis, A. P. Hakansson, C. H. Jones, B. A. Pfeifer, “In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector”, Sci. Adv. 2, e1600264 (2016). link
  • S. Row, Y. Y. Liu, S. Alimperti, S. K. Agarwal, S. T. Andreadis, “Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics”, J. Cell Sci. 129, 2950-2961 (2016). link
  • M. T. Koobatian, S. Row, R. J. Smith, C. Koenigsknecht, S. T. Andreadis, D. D. Swartz, “Successful endothelialization and remodeling of a cell-free small-diameter arterial graft in a large animal model”, Biomaterials 76, 344-358 (2016). link
  • N. Likhite, C. A. Jackson, M. S. Liang, M. C. Krzyzanowski, P. Lei, J. F. Wood, B. Birkaya, K. L. Michaels, S. T. Andreadis, S. D. Clark, M. C. Yu, D. M. Ferkey, “The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling”, Sci. Signal. 8, ra115 (2015). link
  • J. Moharil, P. Lei, J. Tian, D. P. Gaile, S. T. Andreadis, “Lentivirus Live Cell Array for Quantitative Assessment of Gene and Pathway Activation during Myogenic Differentiation of Mesenchymal Stem Cells”, PLoS One 10, e0141365 (2015). link
  • M. T. Koobatian, C. Koenigsknecht, S. Row, S. Andreadis, D. Swartz, “Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring”, J. Vis. Exp. , e52354 (2015). link
  • S. Alimperti, S. T. Andreadis, “CDH2 and CDH11 act as regulators of stem cell fate decisions”, Stem Cell Res. 14, 270-282 (2015). link
  • S. Son, M. S. Liang, P. Lei, X. Z. Xue, E. P. Furlani, S. T. Andreadis, “Magnetofection Mediated Transient NANOG Overexpression Enhances Proliferation and Myogenic Differentiation of Human Hair Follicle Derived Mesenchymal Stem Cells”, Bioconjugate Chem. 26, 1314-1327 (2015). link
  • M. T. Koobatian, M. S. Liang, D. D. Swartz, S. T. Andreadis, “Differential Effects of Culture Senescence and Mechanical Stimulation on the Proliferation and Leiomyogenic Differentiation of MSC from Different Sources: Implications for Engineering Vascular Grafts”, Tissue Eng. Part A 21, 1364-1375 (2015). link
  • S. Row, H. F. Peng, E. M. Schlaich, C. Koenigsknecht, S. T. Andreadis, D. D. Swartz, “Arterial grafts exhibiting unprecedented cellular infiltration and remodeling in vivo: The role of cells in the vascular wall”, Biomaterials 50, 115-126 (2015). link
  • R. J. Smith, M. T. Koobatian, A. Shahini, D. D. Swartz, S. T. Andreadis, “Capture of endothelial cells under flow using immobilized vascular endothelial growth factor”, Biomaterials 51, 303-312 (2015). link
  • R. M. Padmashali, P. Mistriotis, M. S. Liang, S. T. Andreadis, “Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation”, Mol. Ther. 22, 1971-1982 (2014). link
  • Y. Lu, Y. H. Loh, H. Li, M. Cesana, S. B. Ficarro, J. R. Parikh, N. Salomonis, C. X. D. Toh, S. T. Andreadis, C. J. Luckey, J. J. Collins, G. Q. Daley, J. A. Marto, “Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells”, Cell Stem Cell 15, 92-101 (2014). link
  • S. Alimperti, P. Lei, Y. Wen, J. Tian, A. M. Campbell, S. T. Andreadis, “Serum-Free Spheroid Suspension Culture Maintains Mesenchymal Stem Cell Proliferation and Differentiation Potential”, Biotechnol. Prog. 30, 974-983 (2014). link
  • S. Alimperti, H. You, T. George, S. K. Agarwal, S. T. Andreadis, “Cadherin-11 regulates both mesenchymal stem cell differentiation into smooth muscle cells and the development of contractile function in vivo”, J. Cell Sci. 127, 2627-2638 (2014). link
  • M. Ghionzoli, A. Repele, L. Sartiani, G. Costanzi, A. Parenti, V. Spinelli, A. L. David, M. Garriboli, G. Totonelli, J. Tian, S. T. Andreadis, E. Cerbai, A. Mugelli, A. Messineo, A. Pierro, S. Eaton, P. De coppi, “Human amniotic fluid stem cell differentiation along smooth muscle lineage”, Faseb J. 27, 4853-4865 (2013). link
  • R. Padmashali, H. You, N. Karnik, P. Lei, S. T. Andreadis, “Adherens Junction Formation Inhibits Lentivirus Entry and Gene Transfer”, PLoS One 8, e79265 (2013). link
  • C. K. Chen, C. H. Jones, P. Mistriotis, Y. Yu, X. N. Ma, A. Ravikrishnan, M. Jiang, S. T. Andreadis, B. A. Pfeifer, C. Cheng, “Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery”, Biomaterials 34, 9688-9699 (2013). link
  • D. D. Swartz, S. T. Andreadis, “Animal models for vascular tissue-engineering”, Curr. Opin. Biotechnol. 24, 916-925 (2013). link
  • A. D. Mccall, J. W. Nelson, N. J. Leigh, M. E. Duffey, P. Lei, S. T. Andreadis, O. J. Baker, “Growth Factors Polymerized Within Fibrin Hydrogel Promote Amylase Production in Parotid Cells”, Tissue Eng. Part A 19, 2215-2225 (2013). link
  • M. S. Liang, M. Koobatian, P. Lei, D. D. Swartz, S. T. Andreadis, “Differential and synergistic effects of mechanical stimulation and growth factor presentation on vascular wall function”, Biomaterials 34, 7281-7291 (2013). link
  • H. You, R. M. Padmashali, A. Ranganathan, P. Lei, N. Girnius, R. J. Davis, S. T. Andreadis, “JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues”, J. Cell Sci. 126, 2718-2729 (2013). link
  • P. Mistriotis, S. T. Andreadis, “Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine”, Tissue Eng. Part B-Rev. 19, 265-278 (2013). link
  • X. N. He, R. Dziak, X. Yuan, K. Y. Mao, R. Genco, M. Swihart, D. Sarkar, C. Y. Li, C. D. Wang, L. Lu, S. Andreadis, S. Y. Yang, “BMP2 Genetically Engineered MSCs and EPCs Promote Vascularized Bone Regeneration in Rat Critical-Sized Calvarial Bone Defects”, PLoS One 8, e60473 (2013). link
  • S. T. Andreadis, “Give your heart a chance: match the muscle to the vessel”, Cardiovasc. Res. 98, 1-2 (2013). link
  • S. Alimperti, P. Lei, J. Tian, S. T. Andreadis, “A novel lentivirus for quantitative assessment of gene knockdown in stem cell differentiation”, Gene Ther. 19, 1123-1132 (2012). link
  • J. H. Han, P. Mistriotis, P. Lei, D. Wang, S. Liu, S. T. Andreadis, “Nanog Reverses the Effects of Organismal Aging on Mesenchymal Stem Cell Proliferation and Myogenic Differentiation Potential”, Stem Cells 30, 2746-2759 (2012). link
  • V. K. Bajpai, P. Mistriotis, Y. H. Loh, G. Q. Daley, S. T. Andreadis, “Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates”, Cardiovasc. Res. 96, 391-400 (2012). link
  • V. K. Bajpai, S. T. Andreadis, “Stem Cell Sources for Vascular Tissue Engineering and Regeneration”, Tissue Eng. Part B-Rev. 18, 405-425 (2012). link
  • J. Wang, P. Lei, S. T. Andreadis, T. J. Mountziaris, “DETECTION OF DNA HYBRIDIZATION VIA FLUORESCENCE INTENSITY VARIATIONS OF ZnSe-DNA QUANTUM DOT BIOSENSORS”, Anal. Lett. 45, 227-241 (2012). link
  • V. K. Bajpai, P. Mistriotis, S. T. Andreadis, “Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells”, Stem Cell Res. 8, 74-84 (2012). link
  • H. F. Peng, E. M. Schlaich, S. Row, S. T. Andreadis, D. D. Swartz, “A Novel Ovine ex vivo Arteriovenous Shunt Model to Test Vascular Implantability”, Cells Tissues Organs 195, 108-121 (2012). link
  • M. S. Liang, S. T. Andreadis, “Engineering fibrin-binding TGF-beta 1 for sustained signaling and contractile function of MSC based vascular constructs”, Biomaterials 32, 8684-8693 (2011). link
  • M. H. Lee, R. Padmashali, P. Koria, S. T. Andreadis, “JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion”, Faseb J. 25, 613-623 (2011). link
  • L. M. Lugo, P. Lei, S. T. Andreadis, “Vascularization of the Dermal Support Enhances Wound Re-Epithelialization by In Situ Delivery of Epidermal Keratinocytes”, Tissue Eng. Part A 17, 665-675 (2011). link
  • M. H. Lee, R. Padmashali, S. T. Andreadis, “JNK1 Is Required for Lentivirus Entry and Gene Transfer”, J. Virol. 85, 2657-2665 (2011). link
  • R. M. Padmashali, S. T. Andreadis, “Engineering fibrinogen-binding VSV-G envelope for spatially- and cell-controlled lentivirus delivery through fibrin hydrogels”, Biomaterials 32, 3330-3339 (2011). link
  • H. F. Peng, J. Y. Liu, S. T. Andreadis, D. D. Swartz, “Hair Follicle-Derived Smooth Muscle Cells and Small Intestinal Submucosa for Engineering Mechanically Robust and Vasoreactive Vascular Media”, Tissue Eng. Part A 17, 981-990 (2011). link
  • J. Tian, S. Alimperti, P. Lei, S. T. Andreadis, “Lentiviral microarrays for real-time monitoring of gene expression dynamics”, Lab Chip 10, 1967-1975 (2010). link
  • S. D. Raut, P. Lei, R. M. Padmashali, S. T. Andreadis, “Fibrin-mediated lentivirus gene transfer: Implications for lentivirus microarrays”, J. Control. Release 144, 213-220 (2010). link
  • J. H. Han, J. Y. Liu, D. D. Swartz, S. T. Andreadis, “Molecular and functional effects of organismal ageing on smooth muscle cells derived from bone marrow mesenchymal stem cells”, Cardiovasc. Res. 87, 147-155 (2010). link
  • J. Y. Liu, H. F. Peng, S. Gopinath, J. Tian, S. T. Andreadis, “Derivation of Functional Smooth Muscle Cells from Multipotent Human Hair Follicle Mesenchymal Stem Cells”, Tissue Eng. Part A 16, 2553-2564 (2010). link
  • R. Singh, J. Nitsche, S. T. Andreadis, “An Integrated Reaction-Transport Model for DNA Surface Hybridization: Implications for DNA Microarrays”, Ann. Biomed. Eng. 37, 255-269 (2009). link
  • J. Tian, S. T. Andreadis, “Independent and high-level dual-gene expression in adult stem-progenitor cells from a single lentiviral vector”, Gene Ther. 16, 874-884 (2009). link
  • P. Lei, R. M. Padmashali, S. T. Andreadis, “Cell-controlled and spatially arrayed gene delivery from fibrin hydrogels”, Biomaterials 30, 3790-3799 (2009). link
  • R. Singh, P. Lei, S. T. Andreadis, “PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering”, Exp. Cell Res. 315, 2899-2913 (2009). link
  • M. H. Lee, P. Koria, J. Qu, S. T. Andreadis, “JNK phosphorylates beta-catenin and regulates adherens junctions”, Faseb J. 23, 3874-3883 (2009). link
  • L. Yao, J. Y. Liu, S. T. Andreadis, “Composite fibrin scaffolds increase mechanical strength and preserve contractility of tissue engineered blood vessels”, Pharm. Res. 25, 1212-1221 (2008). link
  • J. Tian, P. Lei, S. G. Laychock, S. T. Andreadis, “Regulated insulin delivery from human epidermal cells reverses hyperglycemia”, Mol. Ther. 16, 1146-1153 (2008). link
  • J. Y. Liu, H. F. Peng, S. T. Andreadis, “Contractile smooth muscle cells derived from hair-follicle stem cells”, Cardiovasc. Res. 79, 24-33 (2008). link
  • J. Y. Liu, D. D. Swartz, H. F. Peng, S. F. Gugino, J. A. Russell, S. T. Andreadis, “Functional tissue-engineered blood vessels from bone marrow progenitor cells”, Cardiovasc. Res. 75, 618-628 (2007). link
  • S. T. Andreadis, “Gene-modified tissue-engineered skin: The next generation of skin substitutes”, Adv. Biochem. Eng. Biotechnol. 103, 241-274 (2007). link
  • R. Singh, S. T. Andreadis, “EGF receptor activation decreases retroviral gene transfer through protein kinase C-delta”, Mol. Ther. 15, 369-377 (2007). link
  • K. G. Cornwell, P. Lei, S. T. Andreadis, G. D. Pins, “Crosslinking of discrete self-assembled collagen threads: Effects on mechanical strength and cell-matrix interactions”, J. Biomed. Mater. Res. Part A 80A, 362-371 (2007). link
  • P. Lei, A. Ogunade, K. L. Kirkwood, S. G. Laychock, S. T. Andreadis, “Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: Implications for treatment of diabetes”, Tissue Eng. 13, 2119-2131 (2007). link
  • P. Koria, S. T. Andreadis, “KGF promotes integrin alpha(5) expression through CCAAT/enhancer-binding protein-beta”, Am. J. Physiol.-Cell Physiol. 293, C1020-C1031 (2007). link
  • S. T. Andreadis, D. J. Geer, “Biomimetic approaches to protein and gene delivery for tissue regeneration”, Trends Biotechnol. 24, 331-337 (2006). link
  • P. Koria, S. T. Andreadis, “Epidermal morphogenesis: The transcriptional program of human keratinocytes during stratification”, J. Invest. Dermatol. 126, 1834-1841 (2006). link
  • S. T. Andreadis, “Experimental models and high-throughput diagnostics for tissue regeneration”, Expert Opin. Biol. Ther. 6, 1071-1086 (2006). link
  • B. G. Bajaj, P. Lei, S. T. Andreadis, “Efficient gene transfer to human epidermal keratinocytes on fibronectin: In vitro evidence for transduction of epidermal stem cells”, Mol. Ther. 11, 969-979 (2005). link
  • D. D. Swartz, J. A. Russell, S. T. Andreadis, “Engineering of fibrin-based functional and implantable small-diameter blood vessels”, Am. J. Physiol.-Heart Circul. Physiol. 288, H1451-H1460 (2005). link
  • P. Lei, S. T. Andreadis, “Stoichiometric limitations in assembly of active recombinant retrovirus”, Biotechnol. Bioeng. 90, 781-792 (2005). link
  • L. Yao, D. D. Swartz, S. F. Gugino, J. A. Russell, S. T. Andreadis, “Fibrin-based tissue-engineered blood vessels: Differential effects of biomaterial and culture parameters on mechanical strength and vascular reactivity”, Tissue Eng. 11, 991-1003 (2005). link
  • D. J. Geer, D. D. Swartz, S. T. Andreadis, “Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo”, Am. J. Pathol. 167, 1575-1586 (2005). link
  • S. T. Andreadis, “Gene transfer to epidermal stem cells: implications for tissue engineering”, Expert Opin. Biol. Ther. 4, 783-800 (2004). link
  • D. J. Geer, D. D. Swartz, S. T. Andreadis, “In vivo model of wound healing based on transplanted tissue-engineered skin”, Tissue Eng. 10, 1006-1017 (2004). link
  • P. Koria, D. Brazeau, K. Kirkwood, P. Hayden, M. Klausner, S. T. Andreadis, “Gene expression profile of tissue engineered skin subjected to acute barrier disruption”, J. Invest. Dermatol. 121, 368-382 (2003). link
  • D. J. Geer, S. T. Andreadis, “A novel role of fibrin in epidermal healing: Plasminogen-mediated migration and selective detachment of differentiated keratinocytes”, J. Invest. Dermatol. 121, 1210-1216 (2003). link
  • K. Kirkwood, T. Martin, S. T. Andreadis, Y. J. Kim, “Chemically modified tetracyclines selectively inhibit IL-6 expression in osteoblasts by decreasing mRNA stability”, Biochem. Pharmacol. 66, 1809-1819 (2003). link
  • P. Lei, B. Bajaj, S. T. Andreadis, “Retrovirus-associated heparan sulfate mediates immobilization and gene transfer on recombinant fibronectin”, J. Virol. 76, 8722-8728 (2002). link
  • B. Bajaj, S. Behshad, S. T. Andreadis, “Retroviral gene transfer to human epidermal keratinocytes correlates with integrin expression and is significantly enhanced on fibronectin”, Hum. Gene Ther. 13, 1821-1831 (2002). link
  • D. J. Geer, D. D. Swartz, S. T. Andreadis, “Fibrin promotes migration in a three-dimensional in vitro model of wound regeneration”, Tissue Eng. 8, 787-798 (2002). link
  • P. Lei, B. Bajaj, S. T. Andreadis, “Retrovirus-associated heparan sulfate mediates immobilization and gene transfer on recombinant fibronectin (vol 76, pg 8722, 2002)”, J. Virol. 76, 11176-11176 (2002). link
  • S. T. Andreadis, K. E. Hamoen, M. L. Yarmush, J. R. Morgan, “Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system”, Faseb J. 15, 898-906 (2001). link
  • B. Bajaj, P. Lei, S. T. Andreadis, “High efficiencies of gene transfer with immobilized recombinant retrovirus: Kinetics and optimization”, Biotechnol. Prog. 17, 587-596 (2001). link
  • S. Andreadis, T. Lavery, H. E. Davis, J. M. le doux, M. L. Yarmush, J. R. Morgan, “Toward a more accurate quantitation of the activity of recombinant retroviruses: Alternatives to titer and multiplicity of infection”, J. Virol. 74, 1258-1266 (2000). link
  • S. T. Andreadis, C. M. Roth, J. M. Le doux, J. R. Morgan, M. L. Yarmush, “Large-scale processing of recombinant retroviruses for gene therapy”, Biotechnol. Prog. 15, 1-11 (1999). link
  • S. Andreadis, A. O. Fuller, B. O. Palsson, “Cell cycle dependence of retroviral transduction: An issue of overlapping time scales”, Biotechnol. Bioeng. 58, 272-281 (1998). link
  • B. Palsson, S. Andreadis, “The physico-chemical factors that govern retrovirus-mediated gene transfer”, Exp. Hematol. 25, 94-102 (1997).
  • S. Andreadis, B. O. Palsson, “Coupled effects of polybrene and calf serum on the efficiency of retroviral transduction and the stability of retroviral vectors”, Hum. Gene Ther. 8, 285-291 (1997). link
  • S. T. Andreadis, D. Brott, A. O. Fuller, B. O. Palsson, “Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours”, J. Virol. 71, 7541-7548 (1997).
  • S. T. Andreadis, B. O. Palsson, “Kinetics of retrovirus mediated gene transfer: The importance of intracellular half-life of retroviruses”, J. Theor. Biol. 182, 1-20 (1996). link

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