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Hunter James Kelly Research Institute - University at Buffalo Skip to Content
  • 5/30/17

    Welcome to the Hunter James Kelly Research Institute. HJKRI includes both basic science and clinical science arms where neuroscientists and clinicians are working together to study myelin and its diseases.

  • 5/30/17

    The Wrabetz Laboratory is interested in the molecular genetics of myelination, studied primarily in transgenic mice.

  • 5/30/17

    Our research goal is to understand the transcriptional regulatory network governing the differentiation of oligodendrocytes and central nervous system myelination.

  • 5/30/17

    During the past five years Dr. Paez have found new and novel functions of voltage and store-operated Ca ++ channels as modulators of intracellular Ca ++ levels in oligodendrocytes.

  • 5/30/17

    We study how glial cells form the myelin sheath and support axons during development, in healthy tissues and in diseases such as Charcot-Marie-Tooth, Multiple Sclerosis and Krabbe disease.

  • 5/30/17

    We are studying the cell-autonomous and non-cell-autonomous mechanisms of axon degeneration, a process akin to programmed cell death.

What We Do

Hunter James Kelly Research Institute (HJKRI) is dedicated to unlock the secrets of myelination in the nervous system and to find therapies for diseases of myelin such as Multiple Sclerosis, Leukodystrophies and Charcot-Marie-Tooth disease. HJKRI is supported by the University at BuffaloHunter Hope's Foundation, New York State and extramural funds.

Meet Our Faculty & Staff

Our HJKRI faculty hail from five continents: Africa, Asia, Europe, North America and South America!  We believe this makes for effective and creative research, comprising research approaches literally from all over the world!

Laboratories

The basic research conducted at the HJKRI is based on a multi-disciplinary approach to understand how myelin is formed, how it is damaged in disease, and how it may be repaired.  Myelin diseases cause neurological problems by interfering with neuronal and axon function, so an important focus of HJKRI is to understand, prevent and reverse axonal degeneration.  We use a variety of state-of-the art approaches that include genetic models, bioinformatics, primary cultures of neuronal and glial cells form patients and animal models, neurophysiology and live imaging.  

Updated November 2, 2017