Complex Nanoemulsions for Engineering Novel Soft Nanoparticles
with Applications in Nanomedicine
Emulsions have long been a foundational technology for the solution-phase synthesis of functional particles and materials. More recently, methods to create emulsions with complex internal droplet structure have opened up an entire new design space of complex, multi-phase droplets and particles with potential advantages for foods, consumer products, and medicine. These applicatio...ns have yet to be realized due to significant challenges with current emulsification methods for complex droplets, which are mostly limited to large sizes, poor stability and low throughput. Nanoemulsions – metastable suspensions of nanoscale droplets – overcome these limitations through their scalable processing and metastable nature. However, their engineering is complicated by emergent colloidal and interfacial behavior when droplet sizes are driven to the nanoscale. In this seminar, I will summarize our recent efforts to understand this behavior, and exploit it for the creation of complex nanodroplets and nanoparticles using relatively simple design principles. In particular, we have demonstrated the synthesis of novel nanogel particles with independent control of particle size, internal composition, and mechanical properties that provide unique opportunities for nanomedicine. As a demonstration of their utility, we show how complex nanogels can be used to determine the influence of mechanical properties on the biological transport of nanoparticles. The results indicate particle softness as a critical yet underexplored design parameter for nanobiotechnology, with significant implications for blood circulation, biodistribution, barrier penetration and cellular internalization.
UD PROFESSOR SPEAKS AT SENATE COMMITTEE HEARING
Feng Jiao shares carbon utilization expertise with environment and public works committee
Feng Jiao, a University of Delaware chemical engineering professor spoke at a hearing of the U.S. Senate Committee on Environment and Public Works on April 11, 2018....